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Centre for Drug Candidate Optimisation (CDCO)

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The Centre for Drug Candidate Optimisation (CDCO) is a collaborative research centre based within the Monash Institute of Pharmaceutical Sciences that undertakes drug candidate optimisation to accelerate and enhance drug discovery and development for commercial, not-for-profit and academic research organisations. Drug candidate optimisation is a critical value-creating step in drug discovery/development which enhances the future developmental and commercial potential of candidate drugs through optimisation of their metabolic, physicochemical, pharmacokinetic and bioavailability properties.
Working with us

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View further details of our capabilities and services

Bioavailability and pharmacokinetics

The CulexTM automated in vivo system is used to collect blood and biological samples.

Drug metabolism

Assays to assess metabolism of compounds during lead optimisation and preclinical development.

Physiochemical profiling

To gain qualitative insight into many interactions.

Bioanalysis

Bioanalysis by Mass Spectrometry (LCMS/LC-MSMS) analysis of candidate drugs.

Drug permeability

In vitro cell based methods to simulate gastrointestinal permeability and transporter interactions.

Drug-drug interaction

Assays to assess the potential in vivo interactions with drug metabolising enzymes.

Delivering impact

Multi-million licensing deal for new cancer-fighting compounds

Cancer. Everyone knows someone who’s battling it, beaten it, or sadly succu...
Contacts

Centre for Drug Candidate Optimisation (CDCO)

Monash Institute of Pharmaceutical Sciences (MIPS)
399 Royal Parade, Parkville

VIC 3052, Australia

Facility website

Andrew Powell

andrew.powell@monash.edu

+ 61 (3) 9903 9149

Sue Charman

susan.charman@monash.edu

+ 61 (3) 9903 9626