MATF Antibody Engineering Services
Once the heavy-chain variable, (VH), and light-chain variable, (VL), gene sequences have been obtained from a hybridoma, it is possible to optimise the monoclonal antibody’s properties through antibody engineering approaches. At MATF, we offer a range of antibody engineering services including:
- Design and production of antibody fragments (Fab; Fab’2; scFvs)
- Isotype switching and modification of Fc domains to confer or eliminate antibody-dependent cellular cytotoxicity, (ADCC)
- Antibody humanization
- Antibody affinity maturation
- Bispecific antibody design and production.