Antibody Engineering

MATF Antibody Engineering Services

Once the heavy-chain variable, (VH), and light-chain variable, (VL), gene sequences have been obtained from a hybridoma, it is possible to optimise the monoclonal antibody’s properties through antibody engineering approaches. At MATF, we offer a range of antibody engineering services including:

  • Design and production of antibody fragments (Fab; Fab’2; scFvs)
  • Isotype switching and modification of Fc domains to confer or eliminate antibody-dependent cellular cytotoxicity, (ADCC)
  • Antibody humanization
  • Antibody affinity maturation
  • Bispecific antibody design and production.