2015 Third year Advanced Organic Chemistry (CHM3922).
Prior to 2015, Prof Thang co-supervised 6 PhD students (5 completions,one current) and 3 MSc students (completions) by Research. He had supervised 7 postdoctoral researchers at CSIRO over the past 10 years.
Currently, he directly supervises 2 PhD and 6 MSc students at BUCT in China. He will soon have PhD students and Honours students at Monash Chemistry where he just commenced his professorship in May 2015.
Development of universal (switchable) RAFT agents.
Free radical chemistry through the Nitroxide trapping technique.
Synthesis and properties of polymers of novel architectures.
Synthesis of precision polymers and sequence control polymers.
Design and Synthesis of novel cyclopolymerizable monomers and polymers.
High-throughput methodologies for polymer synthesis
Industrial applications of RAFT-derived polymers.
Bioinspired RAFT polymers as carriers for drug delivery and gene therapeutics.
Cellular delivery with bioinspired RAFT polymeric micelles: targeting and tracking
Research End User and Societal Impacts
Prof Thang is a key co-inventor of the RAFT process. The RAFT technology has generated enormous interest and impact in academia and industry worldwide. The invention of RAFT (1998) has led to the emergence of over 8,320 scientific papers on RAFT published thus far. Some 60 companies/institutions have filed over 500 patents that are dependent on RAFT polymerization, for diverse applications ranging from performance coatings, adhesives and membranes to cosmetics, optoelectronics, biomaterials and drug delivery. Several commercial products are currently on the market such as Asteric™, a new generation of industrial lubricants by Lubrizol Corporation; transfection agent products Trans IT-X2™ by Mirus Bio; electronicmaterials by DuPont and many more from other companies are on the pipeline.Many RAFT agents used in this process are now commercially available fromStrem, Aldrich and Boron Molecular.
Statement of Significant Scientific Contributions
Prof Thang is recognized as a world leader in the field of polymer chemistry, specifically the areas of polymer design and synthesis by free radical polymerization processes, where he has made a number of seminal contributions. The fundamental significance of Thang's outstanding contribution to polymer chemistry is that he has been a key person in an esteemed CSIRO research team (including Dr Ezio Rizzardo and Dr Graeme Moad) that has developed not one, but several controlled/living radical polymerization processes in the past two decades. The most important of these are the Reversible Addition-Fragmentation Chain Transfer (RAFT process); the Nitroxide-Mediated Radical Polymerization (NMP); and the processes of controlling molecular weight and end group functionality in polymers with allylic compounds by the addition-fragmentation chain transfer mechanism. The RAFT process, in particular, has the potential to become the method parexcellence with its versatility, effectiveness and industrial friendliness for the production of a wide range of speciality polymers of well-defined architectures.
Since 2008, he has extended his research with the invention of universal (switchable) RAFT agents that for the first time, the synthesis of blockcopolymers of two characteristically different classes of monomers,more-activated monomers (MAMs) and less-activated monomers (LAMs) has become possible by the RAFT process. In addition, he also works on creating synthetic bioinspired RAFT polymers with various architectures as efficient vehicles for drug and siRNA delivery.
(Source: ISIWeb of Science Core Collection, September 2 2015)
24 Patent families (Derwent Innovation)
15 Book chapters
ISI listed publications (ISI Web of Science)
Life time citations: 14,009
Sum of times of cited withoutself-citations: 13,255
Average citations/paper: 113.34
Citations in Each Year
The latest 20 years are displayed.
Ten Career-Best Publications:
J. Chiefari, Y.K Chong, F. Ercole, J. Krstina, J. Jeffery, T.P. Le, R.T.A. Mayadunne, G.F. Meijs, C.L. Moad, G. Moad, E. Rizzardo and S.H. Thang,"Living Free-Radical Polymerization by Reversible Addition-Fragmentation Chain Transfer: The RAFT Process", Macromolecules, 1998, 31, 5559-5562. IF = 5.800; Citations = 2,862
Y.K. Chong, Frances Ercole, Tam P. Le, Graeme Moad, Ezio Rizzardo and San H. Thang, "A More Versatile Route to Block Copolymers and Other Polymers of Complex Architecture by Living Free Radical Polymerization - The RAFT Process", , Macromolecules, 1999, 32, 2071-2074. IF = 5.800; Citations = 662
San H. Thang, Y.K. Chong, Roshan T.A. Mayadunne, Graeme Moad, Ezio Rizzardo "A Novel Synthesis of Functional Dithioesters, Dithiocarbamates, Xanthates and Trithiocarbonates", Tetrahedron Lett., 1999, 40, 2435-2438. IF = 2.379; Citations = 305
Roshan T.A. Mayadunne, Ezio Rizzardo, John Chiefari, Y.K. Chong, Graeme Moad, San H. Thang, "Living Radical Polymerization with Reversible Addition-Fragmentation Chain Transfer (RAFT Polymerization) Using Dithiocarbamates as Chain Transfer Agents", Macromolecules, 1999, 32, 6977-6980. IF = 5.800; Citations = 419
R.T.A. Mayadunne, E. Rizzardo, J. Chiefari, J. Krstina, G. Moad, A. Postma, S.H. Thang, "Living Polymers by the Use of Trithiocarbonates as Reversible Addition-Fragmentation Chain Transfer (RAFT) Agents: ABA Triblock Copolymers by Radical Polymerization in Two Steps", Macromolecules, 2000, 33, 243-245. IF = 5.800; Citations = 370
Y.K. Chong, J. Krstina, T.P.T. Le, G. Moad, A. Postma, E. Rizzardo, S.H. Thang, "Thiocarbonylthio Compounds [S=C(Ph)S-R] in Free Radical Polymerization with Reversible Addition-Fragmentation Chain Transfer (RAFT Polymerization). Role of Free-Radical Leaving Group (R)" Macromolecules, 2003, 36(7), 2256-2272. IF = 5.800; Citations = 533
J. Chiefari, R.T.A. Mayadunne, C.L. Moad, G. Moad, A. Postma, E. Rizzardo, M.A. Skidmore, S.H. Thang, "Thiocarbonylthio Compounds [S=C(Z)S-R] in Free Radical Polymerization with Reversible Addition-Fragmentation Chain Transfer (RAFT Polymerization). Effect of the Activating Group Z" Macromolecules, 2003, 36(7), 2273-2283. IF = 5.800; Citations = 421
REVIEWS on RAFT:
G. Moad, E.Rizzardo, S. H. Thang, "Living Radical Polymerization by the RAFTprocess", Aust. J. Chem., 2005, 58(6), 379-410. IF = 1.558; Citations = 1,274
G. Moad, E. Rizzardo,S. H. Thang, "Living Radical Polymerization by the RAFT process – AFirst Update", Aust. J. Chem., 2006, 59(10), 669-692. IF = 1.558; Citations = 558
G. Moad, E.Rizzardo, S. H. Thang, "Living Radical Polymerization by the RAFTprocess – A Second Update", Aust. J. Chem., 2009, 62(11), 1402-1472.IF = 1.558; Citations = 412
G. Moad, E.Rizzardo, S. H. Thang, "Living Radical Polymerization by the RAFTprocess – A Third Update", Aust. J. Chem., 2012, 65(8), 985-1076.IF = 1.558; Citations = 198
Graeme Moad, Ezio Rizzardo, San H. Thang, "Radical Addition-Fragmentation Chemistry in Polymer Synthesis", Polymer, 2008, 49, 1079-1131. IF = 3.562; Citations = 672 MassimoBenaglia, John Chiefari, Yen K. Chong,