Arumugam
Laboratory
Cellular Physiology
Welcome to the Arumugam Lab
Our laboratory aims to understand how complex macroscopic properties arise out of molecules and their interactions, regulatory features governing timing precisions, signalling and pattern formation with a primary focus on endosomal trafficking at the level of single cells and in the context of intercellular communications in development.
We're part of the Monash Biomedicine Discovery Institute, and a member of the Development & Stem Cells and Neuroscience Programs, and the Department of Anatomy and Developmental Biology. We are also a member of EMBL Australia.
Dr Senthil Arumugam
My global research connections, partners and funding can be viewed on my Monash Research Profile.
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Our research
A living cell is an active dynamic system where all the non-living constituents of a cell organise themselves through a complex set of interactions, integration of physical principles that gives rise to a ‘living’ cell. Within a living single cell, there are millions of interactions going on between tens of thousands of components. One central component of cellular life is vesicular trafficking on the cytoskeleton networks inside the cells. Quite analogous to how a city is organised (with general public transport systems consisting of buses, light rails, and trains, specific highways for long-distance transport, cars, motorbikes etcetera), the inside of the cells have self-assembled, polymerised proteins building up the tracks, membrane vesicles that carry specific cargoes building up the transport carriers, and the motor proteins that generate the force to pull the membrane vesicles to move along the tracks building up the transport system.
Our lab aims to understand the organisational principles of this transport system, as well as understand their role in orchestrating fundamental processes governing multicellular life, such as patterning during development. Our primary focus areas are:
- Principles of subcellular organization and transport
- Membrane biophysics
- Endocytosis and endosomal regulation by alternative splicing
Endosomal trafficking (in a single cell) of a synthetic construct targeted
simultaneously to golgi and plasma membrane.
simultaneously to golgi and plasma membrane.
Lab members
We are committed to excellence in research.
Join Our Lab
We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.