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Jian Li Laboratory

Antimicrobial Systems Pharmacology
and Drug Discovery

Welcome to the Jian Li Lab

Our group is focused on antimicrobial systems pharmacology and the discovery of novel antibiotics to combat Gram-negative ‘superbugs’.

We're part of the Monash Biomedicine Discovery Institute, a member of the Infection & Immunity and Cardiovascular Disease Programs and the Department of Microbiology.

Professor Jian Li

My global research connections, partners and funding can be viewed on my Monash Research Profile.

Click the links below to connect with me on ORCID and Google Scholar.

Our research

Antibiotics have saved millions of lives over the last century worldwide. Unfortunately, antibiotic resistance presents a significant global medical challenge. Our research aims to optimise antimicrobial use in patients, in particular polymyxins and their combinations; elucidate the mechanisms of antibacterial activity, resistance and toxicity using a systems pharmacology approach; optimise novel, safer polymyxin combination therapy; and develop new-generation polymyxins and novel phage therapy against Gram-negative ‘superbugs’.

  • Optimising clinical use of polymyxins and their synergistic combinations using pharmacokinetics/ pharmacodynamics/toxicodynamics (PK/PD/TD) and systems pharmacology

  • Mechanisms of antibacterial activity, resistance, and toxicity of polymyxins using a multi-disciplinary approach

  • Virtual bacterial cells using systems pharmacology and computational biology

  • Development of new-generation polymyxins, novel formulations, and innovative phage therapy against multidrug-resistant P. aeruginosa, A. baumannii and K. pneumoniae

Lab members

We are committed to excellence in research.

Publications

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News

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Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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