Jian Li Laboratory
Antimicrobial Systems Pharmacology
and Drug Discovery
Welcome to the Jian Li Lab
Our group is focused on antimicrobial systems pharmacology and the discovery of novel antibiotics to combat Gram-negative ‘superbugs’.
We're part of the Monash Biomedicine Discovery Institute, a member of the Infection & Immunity and Cardiovascular Disease Programs and the Department of Microbiology.
Professor Jian Li
My global research connections, partners and funding can be viewed on my Monash Research Profile.
Click the links below to connect with me on ORCID and Google Scholar.
Our research
Antibiotics have saved millions of lives over the last century worldwide. Unfortunately, antibiotic resistance presents a significant global medical challenge. Our research aims to optimise antimicrobial use in patients, in particular polymyxins and their combinations; elucidate the mechanisms of antibacterial activity, resistance and toxicity using a systems pharmacology approach; optimise novel, safer polymyxin combination therapy; and develop new-generation polymyxins and novel phage therapy against Gram-negative ‘superbugs’.
-
Optimising clinical use of polymyxins and their synergistic combinations using pharmacokinetics/ pharmacodynamics/toxicodynamics (PK/PD/TD) and systems pharmacology
-
Mechanisms of antibacterial activity, resistance, and toxicity of polymyxins using a multi-disciplinary approach
-
-
Development of new-generation polymyxins, novel formulations, and innovative phage therapy against multidrug-resistant P. aeruginosa, A. baumannii and K. pneumoniae
Lab members
We are committed to excellence in research.
Join Our Lab
We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.