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Le Nours
Laboratory

Comparative Immunology

Welcome to the Le Nours Lab

While most studies in adaptive immunity have focused on peptide-mediated immunity in humans and mice, our research aims to explore the unchartered territory of lipid- and metabolite-mediated immunity, and gain an evolutionary perspective on the structure and function of MHC-like antigens-presenting molecules.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Infection & Immunity Program and the Department of Biochemistry and Molecular Biology.

Dr Jérôme Le Nours

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on ORCID and LinkedIn.

Our research

By applying multi-disciplinary and highly innovative approaches that include comparative immunology, chemistry, structural biology, cell immunology, advanced atomic and molecular imaging, our lab aims to provide comprehensive and fundamental insights into molecular recognition of non-peptidic antigens (Ags), and gain an evolutionary perspective on the structure and function of MHC-like Ag-presenting molecules. This aspect of immunity represents a new frontier in immunity.

There are a number of pressing fundamental questions that we wish to address through our research program which include:

  1. What is the extent of the chemical diversity of immunogenic non-peptidic antigens (Ags)? Are there more atypical Ags to be discovered in mammalian and non-mammalian species?
  2. How are these lipid and metabolite Ags presented and recognised?
  3. What are the molecular mechanisms that underpin the recognition event and the signalling outcomes?
  4. How did MHC-like molecules evolve to fulfill their molecular functions within a specific species?

Lab members

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Publications

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