Mansouri Lab research
About Dr Farshad Alizadeh Mansouri
Farshad obtained BSc. In Biology (Zoology), MSc. In Medical Physiology and PhD in Neurophysiology. He joined Cognitive Brain Mapping laboratory at RIKEN Brain Science Institute (Wako, Japan) in 1997. Farshad was promoted to a senior staff scientist position at RIKEN institute (2002-2012). Since 1997 he has been investigating the neural basis of executive control and cognitive flexibility by establishing a close animal analogue of Wisconsin Card Sorting Test (WCST). The WCST is a multi-faceted test which is routinely used in clinic to assess cognitive flexibility. Patients with prefrontal cortex damage or neuropsychological disorders such as schizophrenia show impairment in the WCST performance.
- Farshad is the Director of Cognitive Neuroscience laboratory at Monash University.
- He is the Principal Investigator (CIA) in an “ARC Discovery project: DP190103339” to investigate the neural basis of cognitive effects induced by brain stimulation.
- He is an Associate Investigator at ARC Centre of Excellence for Integrative Brain Function (CIBF).
- He is a Visiting Scientist at RIKEN Centre for Brain Science (Japan).
- Understanding the role prefrontal cortex in cognitive flexibility.
- Understanding the role of anterior cingulate cortex in executive control of goal-directed behaviour.
- Studying the modulatory effects of various contextual/environmental factors on decision process.
Visit Dr Mansouri's Monash research profile to see a full listing of current projects.
1. Behavioural and inactivation studies in the context of cognitive tasks to assess executive functions in humans and animal models.
Figure 1: Wisconsin Card Sorting Test (WCST). The WCST is a test of cognitive flexibility in implementing abstract rules (Mansouri et al. Nature Reviews Neuroscience 2009).
2. Examining the neuronal mechanisms underlying executive control of behaviour.
Figure 2: Activity of a single neuron recorded in dorsolateral prefrontal cortex while subjects perform a computerized analogue of the WCST. The subjects had to shift between colour and shape rules. Activity of this prefrontal cortex neuron conveyed information about the relevant rule. Bar graph shows the mean activity during Sample presentation period (Mansouri et al. Journal of Neuroscience 2006; Science 2007).
3. Developing theoretical models to describe the neural architecture of cognitive control in primates.
Figure 3: Mansouri et al. have recently proposed a model to describe the contribution of prefrontal cortical regions to the executive control of behaviour (Nature Reviews Neuroscience, 2017).
In a changing environment we need to select the most appropriate behaviour-guiding rules to achieve our goals. We have been studying the neural substrate and underlying mechanisms of cognitive control and flexibility. We have implemented various techniques such as lesion-behavioural study, single-cell recording and non-invasive brain stimulation in humans and also in animal models to address these questions. Establishing animal models of cognitive tests for recruiting higher cognitive functions such as abstract rule implementation and executive functions has opened new chapters in investigating the neural basis of cognitive processes which previously was considered as exclusive faculties of human brain function. Techniques used in our laboratory include behavioural and electrophysiology studies in animal models and psychophysical and brain stimulation studies in humans.
We collaborate with many scientists and research organisations around the world. Click on the map to see the details for each of these collaborators (dive into specific publications and outputs by clicking on the dots).
Farshad has successfully completed several international joint collaborative studies between RIKEN and the Department of Experimental Psychology at Oxford University (started in 2003). This fruitful collaboration has continued to involve Monash since 2013.
Collaborative studies within Monash
We are currently conducting collaborative studies that involve investigators at the Department of Physiology, School of Psychology and the Department of Physiotherapy.