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Zaph Laboratory

Laboratory of Mucosal Immunity
and Inflammation

Welcome to the Zaph Lab

The overarching goal of research in our lab is to define the cellular and molecular mechanisms that control immunity and inflammation at mucosal sites such as the intestine and the lung.

We're part of the Monash Biomedicine Discovery Institute, and a member of the ImmunityCancer and Development & Stem Cells Programs, and the Department of Biochemistry and Molecular Biology.

Professor Colby Zaph

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on Twitter, ORCID, Google Scholar, LinkedIn and Facebook.

Our research

The various subsets of immune and non-immune cells at mucosal sites are present in a tightly controlled equilibrium that when perturbed by infection, chemicals or genetic predisposition, results in dysregulated inflammation and diseases including asthma and allergy, inflammatory bowel diseases (IBDs), food allergies and cancer. Understanding the molecular and cellular principles underlying mucosal inflammation represents a potential target for identifying novel therapeutics for the treatment of these diseases.

  • Epigenetic regulation of immunity and inflammation at mucosal sites

    We have been at the forefront of defining the epigenetic mechanisms that control T cell differentiation and function.

  • Methylation-dependent regulation of Hippo/YAP and Wnt/beta-Catenin signalling in the intestine

    We have recently identified a novel role for the methyltransferase SETD7 in regulation of the Hippo/YAP signalling pathway

  • Understanding the molecular mechanisms of retinoic acid-mediated regulation of intestinal immune responses

    Micronutrients such as Vitamin A (and its derivative retinoic acid (RA)) play a critical role in intestinal immune homeostasis.

Lab members

We are committed to excellence in research.


View our chosen highlighted key publications.

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We want to share our research discoveries & successes with you.

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Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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