Skip to Content

Combes Laboratory

Development and Disease

Welcome to the Combes Lab

We investigate the mechanisms of embryonic development to understand the origins of disease and guide efforts to recreate human tissues from stem cells.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Development & Stem Cells Program and
the Department of Anatomy and Developmental Biology.

Dr Alex Combes

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on Twitter, ORCID, Google Scholar and Scopus.

Our research

Our research focuses on kidney development and disease. We use single-cell omics, advanced imaging, genetic and molecular approaches to investigate how cell types are specified, maintained, and differentiate. These approaches yield insight into the causes of kidney disease and identify new avenues to improve the production of human kidney tissue from stem cells.

  • Regulation of progenitor cell fate in development and disease

    We seek a deeper understanding of the regulation and behaviour of key progenitor populations in the kidney and how they interact to control the functional capacity of the adult organ.

  • A roadmap to recreate the kidney

    Integrated analysis of single cell and spatial data from mouse and human will provide a roadmap of the developmental programs required to produce and mature specific cell types for disease modelling and drug screening.

Lab members

We are committed to excellence in research.

Publications

View our chosen highlighted key publications.

Read more

News

We want to share our research discoveries & successes with you.

Read more

Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

Find out more