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De Nardo Group

Innate Immune Signalling Group

Welcome to the De Nardo Group

Our groups research focusses on the innate immune response to pathogens and dysregulated host molecules through a better understanding of the underlying cellular signalling pathways that become activated.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Immunity Program,
and the Department of Biochemistry & Molecular Biology.

Dr Dominic De Nardo

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on Twitter, ORCID, Google Scholar and LinkedIn.

Our research

The innate immune system induces a rapid host response following the recognition of pathogens or endogenous danger signals by stimulating the release of inflammatory mediators via the functions of families of highly conserved pattern recognition receptors (PRRs). Our group investigates the mechanisms that control the complex cellular signalling and trafficking pathways that are elicited upon PRR activation. Our research program aims to provide a clearer molecular understanding of innate immune receptors in microbial infection, autoimmune and autoinflammatory disease, as well as uncovering new avenues for harnessing innate immunity for effective cancer immunotherapy.

  • Stimulator of Interferon Genes (STING)-mediated innate immune responses

  • cGAS-STING in host immunity, autoimmunity and cancer

  • Myddosome formation and Toll-like receptor (TLR) signalling

Lab members

We are committed to excellence in research.

Publications

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News

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We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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