Flanagan lab publications

Selected highlight publications

1. BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination.
Parker C*, Chambers AC*, Flanagan DJ, Ho JWY, Collard TJ, Ngo G, Baird DM, Timms P, Morgan RG, Sansom OJ, Williams AC. DNA Repair. 2022 Jul;115:103331. PMID: 35468497. *Equal contribution.

2. Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.  
Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium, van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ. Nat Commun. 2021 Jun 8;12(1):3464. PMID: 34103493

3. NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, Mcgarry L, Englund JI, Webb AT, Scharaw S, Nasreddin N, Hodder MC, Ridgway RA, Minnee E, Sphyris N, Gilchrist E, Najumudeen AK, Romagnolo B, Perret C, Williams AC, Clevers H, Nummela P, Lähde M, Alitalo K, Hietakangas V, Hedley A, Clark W, Nixon C, Kirschner K, Jones EY, Ristimäki A, Leedham SJ, Fish PV, Vincent JP, Katajisto P, Sansom OJ. Nature. 2021 Jun;594(7863):430-435. PMID: 34079124.

4. Wnt Signaling in Cancer: Not a Binary ON:OFF Switch.
Flanagan DJ, Vincan E, Phesse TJ.  Cancer Res. 2019 Dec 1;79(23):5901-5906. PMID: 31431458.

5. Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors With and Without Apc Mutations.
Flanagan DJ, Barker N, Costanzo NSD, Mason EA, Gurney A, Meniel VS, Koushyar S, Austin CR, Ernst M, Pearson HB, Boussioutas A, Clevers H, Phesse TJ, Vincan E. Cancer Res. 2019 Mar 1;79(5):970-981. PMID: 30622113.

Additional publications

A full list of Flanagan Lab publications can be viewed on PubMed.