Goode Lab publications
Selected highlight publications
Transcriptional Adaptation in Cancer
1. Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins.
Trigos AS, Bongiovanni F, Zhang Y, Zethoven M, Tothill R, Pearson R, Papenfuss AT, Goode DL.
Genome Biology. 2024 Apr 29;25(1):110.
doi: 10.1186/s13059-024-03247-1.
2. Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors.
Trigos AS, Pearson RB, Papenfuss AT, Goode DL.
Proceedings of the National Academy of Sciences of the United States of America. 2017 Jun 13;114(24):6406–6411.
doi: 10.1073/pnas.1617743114.
3. MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer.
Cipponi A, Goode DL, Bedo J, McCabe MJ, Pajic M, Croucher DR, Rajal AG, Junankar SR, Saunders DN, Lobachevsky P, Papenfuss AT, Nessem D, Nobis M, Warren SC, Timpson P, Cowley M, Vargas AC, Qiu MR, Generali DG, Keerthikumar S, Nguyen U, Corcoran NM, Long GV, Blay JY, Thomas DM.
Science. 2020 Jun 5;368(6495):1127–1131.
doi: 10.1126/science.aau8768.
Therapy Resistant Prostate Cancer
1. Single-cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology.
Quezada Urban R, Keerthikumar S, Clark A, Wang H, Phipson B, Bakshi A, Ryan A, Thorne H, Taylor RA, Lawrence MG, Risbridger GP, Toivanen R, Goode DL.
Molecular Oncology. 2025 Oct;19(10):2776–2796.
doi: 10.1002/1878-0261.70099.
2. The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology.
Risbridger GP, Clark AK, Porter LH, Toivanen R, Bakshi A, Lister NL, Pook D, Pezaro CJ, Sandhu S, Keerthikumar S, Quezada Urban R, Papargiris M, Kraska J, Madsen HB, Wang H, Richards MG, Niranjan B, O'Dea S, Teng L, Jenkins W, Li Z, Choo N, Ouyang JF, Thorne H, Devereux L, Hicks RJ, Sengupta S, Harewood L, Iddawala M, Azad AA, Goad J, Grummet J, Kourambas J, Kwan EM, Moon D, Murphy DG, Pedersen J, Clouston D, Norden S, Ryan A, Furic L, Goode DL, Frydenberg M, Lawrence MG, Taylor RA.
Nature Communications. 2021 Aug 19;12(1):5049.
doi: 10.1038/s41467-021-25175-5.
Spatial Analysis of the Tumour Immune Microenvironment
1. Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes.
Trigos AS, Pasam A, Banks P, Wallace R, Guo C, Keam S, Thorne H; kConFab; Mitchell C, Lade S, Clouston D, Hakansson A, Liu Y, Blyth B, Murphy D, Lawrentschuk N, Bolton D, Moon D, Darcy P, Haupt Y, Williams SG, Castro E, Olmos D, Goode D, Neeson P, Sandhu S.
Journal for ImmunoTherapy of Cancer. 2022 Jun;10(6):e003744.
doi: 10.1136/jitc-2021-003744
2. Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments.
Feng Y, Yang T, Zhu J, Li M, Doyle M, Ozcoban V, Bass GT, Pizzolla A, Cain L, Weng S, Pasam A, Kocovski N, Huang YK, Keam SP, Speed TP, Neeson PJ, Pearson RB, Sandhu S, Goode DL, Trigos AS.
Nature Communications. 2023 May 15;14(1):2697.
doi: 10.1038/s41467-023-37822-0.
Comparison of Cancer Across Ancestry Groups
1. Putative breast cancer risk variants from populations of South Asian ancestry are under-represented in public variant classification databases.
Rony R, Deng S, Yang S, Doig K, Goode DL.
Breast Cancer Research. 2026 Jan 13;28(1):5.
doi: 10.1186/s13058-025-02166-8.