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Lee Wong Laboratory

Epigenetics and Chromatin Research

Welcome to the Lee Wong Lab

Our research interest is to identify new chromatin factors that control chromosome stability and genetic transmission. We investigate genome-wide epigenetic defects associated with H3.3 and ATRX mutations in cancers, particularly brain and bone cancers.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Development & Stem Cells, Cancer Program and
the Department of Biochemistry and Molecular Biology.

Associate Professor Lee Wong

My global research connections, partners and funding can be viewed on my Monash Research Profile.

Click the links below to connect with me on  ORCID, Google Scholar and LinkedIn.

Our research

The main focus of our group is to new chromatin factors important for maintaining genome stability. With this, we aim to uncover novel epigenetic mechanisms that control chromosome stability and genetic transmission, of which are pertinent to cell growth, tissue differentiation and embryo development.

Our research aim is to uncover fundamental epigenetic mechanisms that regulate transcriptional silencing at repetitive DNA sequences in the genome. Histone variant H3.3 and its chaperone ATRX (Alpha Thalassemia Mental Retardation X-linked) are two key chromatin regulators important for maintaining telomere repeat DNA stability and function. Recent studies have shown that both H3.3 and ATRX are frequently mutated in human cancers, including the brain and bone cancers. We use CRISPR CAS9 gene editing system, highly advanced cellular imaging and high throughput DNA and RNA sequencing to investigate the genome-wide epigenetic defects and DNA instability associated with H3.3 and ATRX mutations in cancers.

Fundamental epigenetic mechanisms that regulate transcriptional silencing at repetitive DNA sequences in the genome

Lab members

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Publications

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News

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We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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