We focus on therapeutically important microbial proteins and aim to characterise how these proteins function on an atomic level. We investigate whether interruption of this function has therapeutic potential and then use our structural information to discover lead molecules and guide drug development.
Associate Professor Sheena McGowan
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We are a structural microbiology laboratory using techniques in molecular and structural biology, microbiology, biochemistry and biophysics to analyse drug targets of interest. We use this mechanistic information to design inhibitors or analogues with potential applications in human medicine. Our laboratory has close connections with many Monash BDI laboratories, as well as the Monash Institute of Pharmaceutical Sciences (Parkville).
Bridging the gap between fundamental microbiology and drug discovery requires a complete understanding of how a new drug target works, both at an atomic level as well as its role in the microorganism.
Our advanced structure-based drug design program has produced potential lead compounds for malaria and cancer as well as new routes to anti-virulence agents for bacteria.
Understanding what controls the activity and specificity of the phage-encoded endolysins is essential to fully exploit their antibacterial potential.
We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.