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Roujeinikova Laboratory

Structural Biology of Bacterial Virulence Factors

Welcome to the Roujeinikova Lab

Due to rising antibiotic resistance, there is a clear demand for new strategies to fight bacterial infections, strategies that involve new or unconventional targets for drug design. Our lab’s focus – and key to the success of these new strategies – is gaining new insights into the molecular basis of bacterial virulence and survival.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Cancer and Infection & Immunity Program
and the Department of Biochemistry and Molecular Biology and Microbiology.

Associate Professor Anna Roujeinikova

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on ORCID and Google Scholar.

Our research

A key to success for developing new strategies to combat bacterial infections, particularly with the rise of antibiotic resistance, lies in strong basic knowledge of the molecular basis of bacterial virulence and survival. The research focus of our group is structure and function of bacterial virulence factors, with emphasis on pathogenic epsilon-proteobacteria, including Helicobacter pylori, Campylobacter jejuni and Campylobacter concisus.

  • Understanding the mechanism of force generation in the bacterial flagellar motor

    Helicobacter pylori must be able to swim by means of its flagella in order to infect the human host and persist for years in the gastric mucosa. We study the structure and function of the force-generating component of the H. pylori flagellar motor.

  • Laws of attraction and repulsion: how is bacterial movement guided?

    Chemotaxis, mediated by chemoreceptors, plays an important role in bacterial survival and virulence. We investigate the structural basis of ligand sensing in chemoreceptors.

  • New targets for the old drugs: exploring the antimicrobial potential of carbonic anhydrase inhibitors

    We evaluate the repurposing potential of carbonic anhydrase inhibitors that have been used clinically as antiglaucoma or antiulcer drugs, in controlling H. pylori infections.

Lab members

We are committed to excellence in research.

Publications

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News

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Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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