The REDDS-2 Study
A trial to assess a novel transfusion schedule in patients with myelodysplastic syndromes
A trial to assess a novel transfusion schedule in patients with myelodysplastic syndromes
About REDDS-2
Building on the success of the REDDS-1 Trial, a feasibility trial which investigated haemoglobin concentration transfusion thresholds in patients with myelodysplastic syndromes (MDS), the REDDS-2 Study is a randomised clinical trial that will assess the feasibility of a weekly red cell transfusion schedule (using matched red cells) and its impact on quality of life and physical function outcomes in patients with transfusion-dependent MDS.
A collaboration between Australia, the UK and the Netherlands, the aim of this study is to inform the design and conduct of a definitive international randomised trial to compare different strategies for red blood cell transfusion in outpatients with MDS.
What does the study involve?
Our research team will assess a novel weekly transfusion schedule, using matched red cells, in patients with transfusion-dependent myelodysplastic syndromes (MDS).
Participating hospitals
The REDDS-2 Study is currently being piloted in hospitals in Australia, the UK and the Netherlands.
Meet the team
This Study is a collaboration between researchers from Monash University, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Radboud University Medical Center, and hospitals in Australia, the UK and the Netherlands.
Recruitment update
We are excited to announce the first patient has been recruited to the trial, in the Netherlands. Although there were delays in the trial due to COVID-19 earlier this year, our sites in Australia and the Netherlands are currently open to recruitment.
First site opens for recruitment in Australia
Monash Health, Clayton is the lead Australian Site for the REDDS-2 Study. In December 2019, Monash Health was the first of three sites in Australia to open for recruitment.
REDDS-2 Study receives ethics approval
The REDDS-2 Study received Human Research Ethics Approval in Australia from Monash Health Human Research Ethics Committee. Monash Health is the lead site in Australia.
Contact us
For further information about REDDS-2 or if you would like to be involved in the Study: