How statins may work to reduce decline
in physical and mental function
Statins (HMG-CoA reductase inhibitors) are a class of drug which is best known for its ability to lower cholesterol. They work by inhibiting a pathway responsible for producing cholesterol (the mevalonate pathway). This interrupts an enzyme in the liver (HMG-CoA reductase) that is essential in the production of cholesterol and other lipids (particularly isoprenoids). By interrupting this pathway it is thought that statins may reduce decline in physical and mental function as well as reducing the incidence of heart disease, stroke and dementia.