.

Key research papers
* denotes joint first author, ^ denotes co-corresponding author

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM (2021) The cryoEM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1. Nat Struct Mol Biol. 28, 982-988.

Roberts MJ, May LT, Keen AC, Liu B, Lam T, Charlton SJ, Rosethorne EM, Halls ML (2021). Inhibition of the proliferation of human lung fibroblasts by prostacyclin receptor agonists is linked to a sustained cAMP signal in the nucleus. Front Pharmacol. 12, 669227.

D'Andrea L, Lucato CM, Marquez EA, Chang YG, Civciristov S, Mastos C, Lupton CJ, Huang C, Elmlund H, Schittenhelm RB, Mitchell CA, Whisstock JC, Halls ML^, Ellisdon AM^ (2021) Structural analysis of the PTEN:P-Rex2 signalling complex reveals how cancer-associated mutantions co-ordinate to hyperactivate Rac1. Sci Signal. 14, eabc4078.

Comeo E, Trinh P, Nguyen AT, Nowell CJ, Kindon ND, Soave M, Stoddart LA, White JM, Hill SJ, Kellam B, Halls ML^, May LT^ & Scammells PJ^ (2021) Development and application of subtype-selective fluorescent antagonists for the study of the human adenosine A₁ receptor in living cells. J Med Chem. 64, 6670-6695.

Gillis RD,  Botteri E, Chang A, Ziegler AI, Chung NC, Pon CK, Shackleford DM, Andreassen BK, Halls ML, Baker JG & Sloan EK (2021) Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients. Eur J Cancer. 147, 106-116.

Mai QN, Shenoy P, Quach T, Retamal JS, Gondin AB, Yeatman HR, Aurelio L, Conner JW, Poole DP, Canals M, Nowell CJ, Graham B, Davis TP, Briddon SJ, Hill SJ, Porter CJH, Bunnett NW^, Halls ML^ & Veldhuis NA^ (2021) A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes. J Biol Chem. 100345

Jimenez-Vargas NN, Gong J, Wisdom MJ, Jensen DD, Latorre R, Hegron A, Teng S, DiCello JJ, Rajasekhar P, Veldhuis NA, Carbone SE, Yu Y, Lopez-Lopez C, Jaramillo-Polanco J, Canals M, Reed DE, Lomax AE, Schmidt BL, Leong KW, Vanner SJ, Halls ML^, Bunnett NW^ & Poole DP^ (2020). Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain. Proc Natl Acad Sci USA. 117(26), 15281-15292.

Civciristov S, Huang C, Liu B, Marquez EA, Gondin AB, Schittenhelm RB, Ellisdon AM, Canals M & Halls ML (2019) Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks. J Biol Chem.  294(44), 16198-16213

Gondin AB, Halls ML, Canals M & Briddon SJ (2019) GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization. Front Mol Neurosci. 12:104.

Patil R, Mohanty B, Liu B, Chandrashekaran IR, Headey SJ, Williams ML, Clements CS, Ilyichova O, Doak BC, Genissel P, Weaver RJ, Vuillard L, Halls ML^, Porter CJH^ & Scanlon MJ^ (2019) A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor alpha agonists. J. Biol. Chem., 294(10), 3720-3734.

Civciristov S, Ellisdon AM, Suderman R, Pon CK, Evans BA, Kleifeld O, Charlton SJ, Hlavacek WS, Canals M & Halls ML (2018) Preassembled GPCR signalling complexes mediate distinct cellular responses to ultralow ligand concentrations. Sci. Signal., 11(551), eaan1188.

Jensen DD*, Lieu T*, Halls ML*, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herebrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McClusky A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M & Bunnett NWB (2017) Neurokinin 1 receptor signalling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief. Sci. Trans. Med.,9(392), eaal3447.

Furness SG, Liang YL, Nowell CJ, Halls ML, Wookey PJ, Dal Maso E, Inoue A, Christopoulos A, Wootten D & Sexton PM (2016) Ligand-dependent modulation of G protein conformation alters drug efficacy. Cell,167(3), 739-749.

Halls ML^, Yeatman HR, Nowell CJ, Thompson GL, Gondin AB, Civciristov S, Bunnett NW, Lambert NA, Poole DP & Canals M^ (2016) Plasma membrane localisation of the μ-opioid receptor controls spatiotemporal signalling. Sci. Signal., 9(414), ra16.

Ercole F, Mansfeld FM, Kavallaris M, Whittaker MR, Quinn JF^, Halls ML^ & Davis TP^ (2016) Macromolecular hydrogen sulphide donors trigger spatiotemporally confined changes in cell signalling. Biomacromolecules, 17(1), 371-383.

Pon CK, Lane JR, Sloan EK & Halls ML (2016) The β₂-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion. FASEB J., 30(3), 1144-1154.

Halls ML^, Poole DP, Ellisdon AM, Nowell CJ & Canals M^ (2015) Detection and quantification of intracellular signalling using FRET-based biosensors and high content imaging. Meth. Mol. Biol., 1335, 131-161.

Halls ML & Cooper DMF (2010). Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex. EMBO J., 29(16), 2772-87. Recommended by The Faculty of 1000.

Halls ML, Bathgate RAD & Summers RJ (2006). Relaxin family peptide receptors, RXFP1 and RXFP2, modulate cAMP signalling by distinct mechanisms. Mol. Pharmacol., 70(1), 214-26. Recommended by The Faculty of 1000.

Key Reviews
* denotes joint first author, ^ denotes co-corresponding author

Civciristov S & Halls ML (2019) Signalling in response to sub-picomolar concentrations of active compounds: pushing the boundaries of G protein-coupled receptor sensitivity. Br. J. Pharmacol., 176(14), 2382-2401.

Halls ML (2019) Localised GPCR signalling as revealed by FRET biosensors. Curr. Opin. Cell Biol., 57, 48-56.

Halls ML^ & Canals M^ (2018) Genetically encoded FRET biosensors to illuminate compartmentalised GPCR signalling. Trends Pharmacol. Sci., 39(2), 148-157.

Halls ML & Cooper DMF (2017) Adenylyl cyclase signalling complexes – pharmacological challenges and opportunities. Pharmcol. Ther., 172, 171-180.

Ellisdon AM & Halls ML (2016) Compartmentalisation of GPCR signalling controls unique cellular responses. Biochem. Soc. Trans., 44(2), 562-567