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Chai Laboratory

Insulin-Regulated Aminopeptidase (IRAP)

Welcome to the Chai Lab

Our research is focussed on insulin-regulated aminopeptidase (IRAP) particularly in diseased states.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Metabolism, Diabetes & Obesity and Cardiovascular Disease and Neuroscience Program and the Department of Physiology.

Associate Professor Siew Chai

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on ORCID and LinkedIn.

Our research

Metallo-peptidases cleave amino acids from either the N- and C-termini of peptide hormones to either generate or degrade bioactive peptides. These enzymes play important roles in the body and alterations in their activities can impact on a diverse range of physiological processes in both healthy and diseased states. Research in our laboratory is focussed on the role of the enzyme, insulin-regulated aminopeptidase (IRAP).

I.  Development and Characterisation of New Classes of IRAP Inhibitors
II. Role of IRAP in the brain
III.Role of IRAP in mediating the neuro-inflammatory response to ischemic damage
IV.Role of IRAP in cardiovascular and renal function
V.Role of IRAP in the development of tissue fibrosis

Lab members

We are committed to excellence in research.


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Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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