Professor Roger Daly
Signalling Network Laboratory
Welcome to the Daly Lab
The goal of the Signalling Network Laboratory is to characterise - at the molecular level -how signalling is altered in cancer, and thereby identify novel therapeutic strategies for particular poor prognosis human cancers, as well as biomarkers that aid classification of patients towards optimal treatments.
We're part of the Monash Biomedicine Discovery Institute, and a member of the Cancer Program and the Department of Biochemistry and Molecular Biology.
Professor Roger Daly
My global research connections, partners and funding can be viewed on my Monash Research Profile.
If you are a student interested in doing research in our lab, visit Supervisor Connect.
Click the links below to connect with me on ORCID and Google Scholar.
Our research
The goal of the Signalling Network Laboratory is to identify novel therapeutic targets and biomarkers for particular human cancers, including triple negative breast cancer, prostate, pancreatic and gastric cancer, through detailed characterisation of intracellular signalling events. What sets us apart is that we address signalling at a network level, through an integrated strategy that combines phosphoproteomic profiling of cancer subtypes and global interrogation of the human kinome with functional genomics, computational biology and bioinformatics.
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Phosphorylation-based signalling networks in cancer
Integrating mass spectrometry-based proteomics with functional genomics and computational biology to characterise kinase-based signalling networks in triple negative breast cancer and identify improved therapeutic strategies.
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Intercellular communication in the tumour microenvironment
The tumour microenvironment (TME) plays a major role in cancer development and progression, and characterisation of intercellular signalling networks in the TME offers novel opportunities for research translation.
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Network-level interrogation of the PEAK family of pseudokinase scaffolds
This research area focuses on the PEAK family of oncogenic scaffolds and aims to define the protein interaction networks mediated by different PEAK complexes and their functional roles.
Lab members
We are committed to excellence in research.
Join Our Lab
We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.