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Formosa Laboratory

Mitochondrial Biology, Metabolism and Disease

Welcome to the Formosa Group

Our group is interested in uncovering how mitochondria work in our cells, how they build their intricate and complex machinery and how they contribute to cellular health. We use this knowledge to understand the molecular basis of mitochondrial defects in several diseases including mitochondrial disease to improve the diagnosis of patients and uncover avenues for future treatment development.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Metabolism, Diabetes & Obesity Program,
and the Department of Biochemistry and Molecular Biology.

Dr Luke Formosa

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on X (formerly Twitter), ORCID, Google Scholar and Scopus.

Our research

Mitochondria play a pivotal role in almost all eukaryotic cells, where they act as miniature factories to produce many of the building blocks of life, as well as the energy your cells need to grow and divide. We are interested in how mitochondria build the enzymes required for the formation of ATP.

  • 1. Understanding the co-translational insertion of proteins into the mitochondrial inner membrane

  • 2. Discovery of new proteins involved in the assembly of the respiratory chain

  • 3. Identifying metabolite transporters in mitochondria

  • 4. Investigating the metabolic changes due to mitochondrial dysfunction

Lab members

We are committed to excellence in research.

Formosa Group 2025

The Formosa Group works as part of the Ryan Lab (lab photo 2025)

Publications

View our chosen highlighted key publications.

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News

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Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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