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Harrison and Walton Laboratory

Growth Factor Therapeutics

Welcome to the Harrison and Walton Lab

Our laboratory modifies the body’s naturally occurring growth factors (TGF-β proteins) as therapies for reproductive and metabolic disorders.

We're both part of the Monash Biomedicine Discovery Institute, and members of the Metabolism, Diabetes & Obesity and Development & Stem Cells Programs and the Department of Physiology.

Associate Professor Craig Harrison

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on ORCID and Google Scholar.

Dr Kelly Walton

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on Twitter, ORCID and Google Scholar.

Our research

In female mammals, TGF-β family proteins are intricately involved in the control of folliculogenesis and ovulation, and the establishment and maintenance of pregnancy. Several TGF-β ligands also serve as endocrine hormones to integrate the reproductive status of the ovary to the female’s physiological condition. Such biological impact identifies these proteins as promising therapeutic targets to treat reproductive disorders and postmenopausal complications, including osteoporosis, muscle wasting and obesity.

Based on our understanding of the synthesis/activation of TGF-β proteins, we have generated numerous biologics to modulate TGF-β family signalling and developed new genetic models that display reproductive and/or metabolic pathologies. Our research program is centred on the use of these novel tools to improve female health outcomes.

  • Defining the physiology and therapeutic potential of inhibin

  • Targeting activin to counter life-threatening cancer cachexia

  • Therapeutic potential of TGF-β proteins for the treatment of female infertility

Lab members

We are committed to excellence in research.

Publications

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News

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Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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