Mitchell lab publications
Selected highlight publications
1. Davies, Elizabeth M., Gurung, Rajendra, Le, Kai Qin, Roan, Katherine T. T., Harvey, Richard P., Mitchell, Geraldine M., Schwarz, Quenten & Mitchell, Christina A. 2023, ‘PI(4,5)P2-dependent regulation of endothelial tip cell specification contributes to angiogenesis’, Science Advances, vol. 9, no. 13, doi:10.1126/sciadv.add6911.
2. Samuel J Rodgers, Emily I Jones, Senthil Arumugam, Sabryn A Hamila, Jill Danne, Rajendra Gurung, Matthew J Eramo, Randini Nanayakkara, Georg Ramm, Meagan J McGrath & Christina A Mitchell 2022,‘Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy’, The EMBO Journal, vol. 41, no. 19, doi:10.15252/embj.2021110398.
3. Samuel J. Rodgers, Lisa M. Ooms, Viola M. J. Oorschot, Ralf B. Schittenhelm, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J. Eramo, Absorn Sriratana, Clare G. Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E. Abud, Georg Ramm, Antonella Papa, Andrew M. Ellisdon, Roger J. Daly, Catriona A. McLean & Christina A. Mitchell 2021, ‘INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer’, Nature Communications, vol. 12, no. 1, doi:10.1038/s41467-021-23241-6.
4. Sarah E Conduit , Elizabeth M Davies , Alex J Fulcher , Viola Oorschot , Christina A Mitchell , 2021. ‘Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone’, Frontiers in Cell and Developmental Biology, vol. 9:634649. doi: 10.3389/fcell.2021.634649.
5. Meagan J. McGrath, Matthew J. Eramo, Rajendra Gurung, Absorn Sriratana, Stefan M. Gehrig, Gordon S. Lynch, Sonia Raveena Lourdes, Frank Koentgen, Sandra J. Feeney, Michael Lazarou, Catriona A. McLean & Christina A. Mitchell 2021, ‘Defective lysosome reformation during autophagy causes skeletal muscle disease’, Journal of Clinical Investigation, vol. 131, no. 1, doi:10.1172/jci135124.
6. Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Catriona A. McLean, Lisa M. Ooms & Christina A. Mitchell 2020, ‘PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis’, Proceedings of the National Academy of Sciences, vol. 117, no. 45, pp. 28056–28067, doi:10.1073/pnas.2006445117.
7. Christina A Mitchell , Martine F Roussel , Leonie Walsh , Ashani T Weeraratna, 2019. ‘Women in cancer research’, Nature Reviews Cancer, vol. 19, no. 10:547-552. doi: 10.1038/s41568-019-0176-y.
8. S E Conduit , V Ramaswamy , M Remke , D N Watkins, B J Wainwright, M D Taylor , C A Mitchell , J M Dyson, 2017. ‘A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma’, Oncogene, vol. 36, no. 43:5969-5984. doi: 10.1038/onc.2017.208.
9. Jennifer M. Dyson, Sarah E. Conduit, Sandra J. Feeney, Sandra Hakim, Tia DiTommaso, Alex J. Fulcher, Absorn Sriratana, Georg Ramm, Kristy A. Horan, Rajendra Gurung, Carol Wicking, Ian Smyth & Christina A. Mitchell 2016, ‘INPP5E regulates phosphoinositide dependent cilia transition zone function’, The Journal of Cell Biology, vol. 216, no. 1, pp. 247–263, doi:10.1083/jcb.201511055.
10. Ooms, L.M., Binge, L.C., Davies, E.M., Rahman, P, Conway, J.R., Gurung, R, Ferguson, D.T., Papa, A, Fedele, C.G., Vieusseux, J.L., Chai, R.C., Koentgen, F, Price, J.T., Tiganis, T, Timpson, P, McLean, C.A. & Mitchell, C.A. 2015, ‘The Inositol Polyphosphate 5 Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.’, Cancer Cell, vol. 28, no. 2, pp. 155-69. doi: 10.1016/j.ccell.2015.07.003
11. Fedele, C.J., Ooms, L.M., Ho, M, Vieusseux, J, O’Toole, S.A., Millar, E.K., Lopez-Knowles, E, Sriritana, A, Gurung, R, Bagli etto, L, Giles, G.G., Bailey, C.G., Rasko, J.E., Shields, B.J., Price, J.T., Majerus, P.W., Sutherland, R.L., Tiganis, T, McLean, C.A. &Mitchell, C.A. 2010, ‘Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.’, Proc Natl Acad Sci USA, vol. 107, no. 51, pp. 22231-6. doi: 10.1073/pnas.1015245107
12. Joachim Schessl , Ana L Taratuto, Caroline Sewry, Roberta Battini, Steven S Chin, Baijayanta Maiti, Alberto L Dubrovsky, Marcela G Erro, Graciela Espada, Monica Robertella, Maria Saccoliti, Patricia Olmos, Leslie R Bridges, Peter Standring, Ying Hu, Yaqun Zou, Kathryn J Swoboda, Mena Scavina, Hans-Hilmar Goebel, Christina A Mitchell, Kevin M Flanigan, Francesco Muntoni, Carsten G Bönnemann, 2009. ‘Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1’, Brain, vol. 132, no. Pt 2:452-64. doi: 10.1093/brain/awn325.
13. Belinda S Cowling , Meagan J McGrath, Mai-Anh Nguyen, Denny L Cottle, Anthony J Kee, Susan Brown, Joachim Schessl, Yaqun Zou, Josephine Joya, Carsten G Bönnemann, Edna C Hardeman, Christina A Mitchell, 2008. ‘Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy’, Journal of Cell Biology, vol. 183, no. 6:1033-48. doi: 10.1083/jcb.200804077.
14. Joachim Schessl , Yaqun Zou, Meagan J McGrath, Belinda S Cowling, Baijayanta Maiti, Steven S Chin, Caroline Sewry, Roberta Battini, Ying Hu, Denny L Cottle, Michael Rosenblatt, Lynn Spruce, Arupa Ganguly, Janbernd Kirschner, Alexander R Judkins, Jeffrey A Golden, Hans-Hilmar Goebel, Francesco Muntoni, Kevin M Flanigan, Christina A Mitchell, Carsten G Bönnemann, 2008. Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy’, Journal of Clinical Investigation, vol. 118, no. 3:904-12. doi: 10.1172/JCI34450.
Additional publications
A full list of Mitchell Lab publications can be viewed on PubMed.