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Nguyen lab publications

Selected highlight publications

1. Padman, BS, Nguyen, TN, Uoselis, L, Skulsuppaisarn, M, Nguyen, LK, Lazarou, M 2019, LC3/GABARAPs drive ubiquitinindependent recruitment of Optineurin and NDP52 to amplify mitophagy, Nature Communications, vol.1, no. 10, pp. 408, doi:

2. Shin S-Y, Müller AK, Verma N, Lev S, and Nguyen, LK#. Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for Triple-negative breast cancer. PLOS Computational Biology, 2018 Jun 19;14(6):e1006192. doi: 10.1371/journal.pcbi.1006192. (#corresponding).

3. Varusai, T. and Nguyen, LK#. Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR. Nature Scientific Reports, 2018. 8(1):643 doi: 10.1038/s41598-017-18400-z. (#corresponding).

4. Byrne KM, Monsefi N, Volinsky N, Dobrzyński M, Birtwistle MR, Tsyganov MA, Kida K, Kolch W, Nguyen LK #, Kriegsheim AV#, Kholodenko BN#. Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches. Cell Systems. 2016; 2:38-48.(#co-senior authors – equal contribution).

5. Varusai TM, Kolch W, Kholodenko BN, Nguyen LK #. Protein-protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose-responses. Molecular Biosystems. 2015 Sep 15;11(10):2750-62.

6. Romano D #, Nguyen LK #, Matallanas D, Halasz M, Doherty C, Kholodenko BN, Kolch W. Protein interaction switches coordinate oncogenic and apoptotic signaling. (2014) Nature Cell Biology. 2014 Jul;16(7):673-84. (# Lead modeler and experimentalist)

7. Nguyen LK #, Degasperi A, Cotter P, Kholodenko BN. DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks. Scientific Reports. 2015 Jul 29; 5:12569. (#corresponding)

8. Nguyen LK, Cavadas MA, Scholz CC, Fitzpatrick SF, Bruning U, Cummins EP, Tambuwala MM, Manresa MC, Kholodenko BN, Taylor CT, Cheong A. A dynamic model of the hypoxia-inducible factor (HIF) network. Journal of Cell Science. 2013; 126(Pt 6): p. 1454-63.

9. Nguyen LK, Muñoz-García J, Maccario H, Ciechanover A, Kolch W, Kholodenko BN. Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system. PLOS Computational Biology, 2011 Dec 7(12): p. e1002317.

10. Nguyen LK. Regulation of oscillation dynamics in biochemical systems with dual negative feedback loops. Journal of the Royal Society Interface. 2012; 9(73): 1998-2010.

Additional publications

A full list of Nguyen Lab publications can be viewed on PubMed.