Ryan Laboratory
Mitochondrial Biology and Disease
Welcome to the Ryan Lab
We study how mitochondria work in our cells to make energy and what goes wrong in disease.
We're part of the Monash Biomedicine Discovery Institute, and a member of the Metabolism, Diabetes & Obesity and Neuroscience Programs, and the Department of Biochemistry and Molecular Biology.
Professor Mike Ryan
My global research connections, partners and funding can be viewed on my Monash Research Profile.
If you are a student interested in doing research in our lab, visit Supervisor Connect.
Click the links below to connect with me on Twitter, ORCID, Google Scholar and LinkedIn.
Our research
Mitochondrial defects cause degenerative diseases and often lead to infant death. Mitochondria are generally found as a reticulated network radiating from the nucleus with individual mitochondria undergoing fission and fusion for proper distribution, quality control, and stress responses. Our lab investigates biochemical and cell biological processes related to these areas. Research projects are designed to ensure each student encounters a range of techniques and along with weekly lab meetings, will give them expertise for future scientific and non-scientific careers.
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Mitochondrial disease
Defects in oxidative phosphorylation (OXPHOS) result in human mitochondrial disease and affect ~1/5,000 live births.
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Mitochondrial dynamics
Mitochondria form a network that is finely tuned to the needs of the cell.
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Functional analysis of the human mitochondrial proteome
While we understand many aspects of mitochondrial function, we still do not fully appreciate the roles played by many individual proteins present in the organelle.
Lab members
We are committed to excellence in research.
The Ryan Lab 2019
Join Our Lab
We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.