Skip to Content

Ryan Laboratory

Mitochondrial Biology and Disease

Welcome to the Ryan Lab

We study how mitochondria work in our cells to make energy and what goes wrong in disease.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Metabolism, Diabetes & Obesity and Neuroscience Programs, and the Department of Biochemistry and Molecular Biology.

Professor Mike Ryan

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on Twitter, ORCID, Google Scholar and LinkedIn.

Our research

Mitochondrial defects cause degenerative diseases and often lead to infant death. Mitochondria are generally found as a reticulated network radiating from the nucleus with individual mitochondria undergoing fission and fusion for proper distribution, quality control, and stress responses. Our lab investigates biochemical and cell biological processes related to these areas. Research projects are designed to ensure each student encounters a range of techniques and along with weekly lab meetings, will give them expertise for future scientific and non-scientific careers.

  • Mitochondrial disease

    Defects in oxidative phosphorylation (OXPHOS) result in human mitochondrial disease and affect ~1/5,000 live births.

  • Mitochondrial dynamics

    Mitochondria form a network that is finely tuned to the needs of the cell.

  • Functional analysis of the human mitochondrial proteome

    While we understand many aspects of mitochondrial function, we still do not fully appreciate the roles played by many individual proteins present in the organelle.

Lab members

We are committed to excellence in research.

The Ryan Lab 2019

Publications

View our chosen highlighted key publications.

Read more

News

We want to share our research discoveries & successes with you.

Read more

Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

Find out more