Stone Laboratory
Chemokine-Receptor Interaction
Welcome to the Stone Lab
Our group is investigating several important aspects of chemokine and chemokine receptor biochemistry with the overall goals of better understanding and ultimately controlling their biological functions.
We're part of the Monash Biomedicine Discovery Institute, and a member of the Immunity and Cardiovascular Disease Programs, and the Department of Biochemistry and Molecular Biology.
Professor Martin Stone
My global research connections, partners and funding can be viewed on my Monash Research Profile.
If you are a student interested in doing research in our lab, visit Supervisor Connect.
Click the links below to connect with me on ORCID and Google Scholar.
Our research
Inflammation is the response of a tissue and its microvascular system to injury or infection. A hallmark of inflammation is the accumulation of leukocytes (white blood cells), which remove pathogens and necrotic tissue by phagocytosis and proteolytic degradation. However, excessive leukocyte recruitment or activity leads to the release of toxic substances and degradation of healthy tissue, i.e. inflammatory disease.
Leukocyte recruitment in inflammation is controlled by the expression and secretion of small proteins called chemokines at the site of inflammation and by the subsequent interaction of those chemokines with chemokine receptors located on the surfaces of circulating leukocytes. A detailed understanding of chemokinereceptor interactions is required in order to rationally develop novel therapeutic agents against inflammatory diseases.
Lab members
We are committed to excellence in research.
Join Our Lab
We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.