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Click the links below to connect with me on ORCID and Google Scholar.
Inflammation is the response of a tissue and its microvascular system to injury or infection. A hallmark of inflammation is the accumulation of leukocytes (white blood cells), which remove pathogens and necrotic tissue by phagocytosis and proteolytic degradation. However, excessive leukocyte recruitment or activity leads to the release of toxic substances and degradation of healthy tissue, i.e. inflammatory disease.
Leukocyte recruitment in inflammation is controlled by the expression and secretion of small proteins called chemokines at the site of inflammation and by the subsequent interaction of those chemokines with chemokine receptors located on the surfaces of circulating leukocytes. A detailed understanding of chemokinereceptor interactions is required in order to rationally develop novel therapeutic agents against inflammatory diseases.
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