Tiganis lab publications

Selected highlight publications

Metabolism

Gurzov EN, Tran M, Fernandez-Rojo MA, Merry TL, Zhang X, Yu Y, Fukushima A, Waters MJ, Watt MJ, Andrikopoulos S, Neel BG, Tiganis T (2014) Hepatic Oxidative Stress Promotes insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2. Cell Metabolism. 20(1), 85-102.
Full text URL: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(14)00219-8

Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T (2015). Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat. Cell. 160(1-2):88-104.
Full text URL: https://www.cell.com/cell/fulltext/S0092-8674(14)01593-1

Dodd GT Andrews ZB, Simonds S, Michael NJ, DeVeer M, Brüning JC, Spanswick D, Cowley MA, and Tiganis T (2017). A hypothalamic phosphatase switch coordinates energy expenditure with feeding. Cell Metabolism. 26(2): 375-393.
Full text URL: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30434-5

Dodd GT, Xirouchaki CE, Eramo M, Mitchell CA, Andrews ZB, Henry BA, Cowley MA, Tiganis T. (2019) Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity. Cell Reports. 28(11), 2905-2922
Full text URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31052-6

Balland E, Chen W, Dodd GT, Conductier G, Coppari R, Tiganis T*, Cowley MA*. (2019) Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice. Cell Reports, 26(2), 346-355. * Co-corresponding
Full text URL: https://www.cell.com/cell-reports/fulltext/S2211-1247(18)32006-0

Dodd, G.T., Kim, S.J., Méquinion, M., Xirouchaki, C.E., Brüning, J.C., Andrews, Z.B., Tiganis, T. (2021) Insulin Signalling in AgRP Neurons Regulates Meal Size to Limit Glucose Excursions and Insulin Resistance. Science Advances. 7(9), eabf4100.
Full text URL: https://www.science.org/doi/10.1126/sciadv.abf4100

Xirouchaki CE, Jia Y, McGrath MJ, Greatorex S, Tran M, Merry TL, Hong D, Eramo MJ, Broome SC, Woodhead JST, D'souza RF, Gallagher J, Salimova E, Huang C, Schittenhelm RB, Sadoshima J, Watt MJ, Mitchell CA, Tiganis T. (2021) Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance. Science Advances. 7(51):eabl4988. 
Full text URL: https://www.science.org/doi/10.1126/sciadv.abl4988

Greatorex S, Kaur S, Xirouchaki CE, Goh PK, Wiede F, Genders AJ, Tran M, Jia Y, Raajendiran A, Brown WA, McLean CA, Sadoshima J, Watt MJ, Tiganis T (2024) 
Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity Journal of Clinical Investigation;134(3):e162533.
Full text URL: https://www.jci.org/articles/view/162533/pdf

Cancer

Grohmann M, Wiede F, Dodd GT, Gurzov EN, Ooi GJ, Butt T, Rasmiena AA, Kaur S, Gulati T, Goh PK, Treloar AE, Archer S, Brown WA, Muller M, Watt MJ, Ohara O, McLean CA, Tiganis T (2018). Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 175(5), 1289-1306.
Full text URL: https://www.cell.com/cell/fulltext/S0092-8674(18)31304-7

Wiede F, Lu KH, Du X, Liang S, Hochheiser K, Dodd GT, Goh PK, Kearney C, Meyran D, Beavis PA, Henderson MA, Park SL, Waithman J, Zhang S, Zhang ZY, Oliaro J, Gebhardt T, Darcy PK, Tiganis T. (2020) PTPN2 Phosphatase Deletion in T Cells Promotes Anti-Tumour Immunity and CAR T-cell Efficacy in Solid Tumours. The EMBO Journal. 39(2). 
Full text URL: https://www.embopress.org/doi/full/10.15252/embj.2019103637

Goh PK, Wiede F, Zeissig MN, Britt KL, Liang S, Molloy T, Goode N, Xu R, Loi S, Muller M, Humbert PO, McLean C, Tiganis T. (2022) PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer. Science Advances. 8(8):eabk3338.
Full text URL: https://www.science.org/doi/10.1126/sciadv.abk3338

Du X, Darcy PK, Wiede F, Tiganis T. (2022) Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors. Molecular Cell Biology. 42(3):e0044921. 
Full text URL: https://journals.asm.org/doi/10.1128/mcb.00449-21

Wiede F, Lu KH, Du X, Zeissig MN, Xu R, Goh PK, Xirouchaki CE, Hogarth SJ, Greatorex S, Sek K, Daly RJ, Beavis PA, Darcy PK, Tonks NK, Tiganis T. (2022) PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity. Cancer Discoveries. 12(3):752-773.
Full text URL: https://aacrjournals.org/cancerdiscovery/article/12/3/752/681920/PTP1B-Is-an-Intracellular-Checkpoint-that-Limits-T

Du X, Goh PK, Ma C, Coughlan E, Greatorex S, Porter LH, Russ B, Cummins KD, Sek K, Slaney CY, Scott AM, Oliaro J, Neeson PJ, Risbridger GP, Taylor RA, Trapani JA, Turner SJ, Darcy PK, Wiede F, Tiganis T (2025)
Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models Science Translational Medicine; 17(822):eadk0627.Full text URL: https://www.science.org/doi/10.1126/scitranslmed.adk0627
Monash Biomedicine Discovery Institute (BDI) News: From blood to solid tumours: a new way to power up CAR T Cell Therapy

Immunity

Wiede F, Shields BJ, Chew SH, Kyparissoudis K, van Vliet C, Galic S, Tremblay ML, Russell SM, Godfrey DI, and T Tiganis. (2011). T cell protein tyrosine phosphatase attenuates T cell signaling for the maintenance of tolerance in mice. The Journal of Clinical Investigations. 121(12):4758-74.
Full text URL: https://www.jci.org/articles/view/59492

Wiede F, Gruta NLL, Tiganis T (2014) PTPN2 Attenuates T-cell Lymphopenia-Induced Proliferation. Nature Communication. 
Full text URL: https://www.nature.com/articles/ncomms4073

Wiede F, Dudakov JA, Lu KH, Dodd GT, Butt T, Godfrey DI, Strasser A, Boyd RL, Tiganis T(2017). PTPN2 regulates T cell lineage commitment and ab versus gd specification. Journal of Experimental Medicine. 214(9):2733-2758.
Full text URL: https://rupress.org/jem/article/214/9/2733/42484/PTPN2-regulates-T-cell-lineage-commitment-and

Wiede F, Brodnicki TC, Goh PK, Leong YA, Jones GW, Yu D, Baxter AG, Jones SA, Kay TWH, Tiganis T (2019) T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities. Diabetes. 68(6), 1251-1266. 
Full text URL: https://diabetes.diabetesjournals.org/content/68/6/1251

Additional publications

A full list of Tiganis Lab publications can be viewed on PubMed.