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Challis Laboratory

Natural Products Chemistry
and Biology

Welcome to the Challis Lab

We work on the discovery, biosynthesis, bioengineering and mechanism of action of antibiotics and other bioactive metabolites produced by bacteria.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Infection Program, and the Department of Biochemistry and Molecular Biology.

Professor Challis holds a joint appointment with the Monash BDI and with the Department of Chemistry at the University of Warwick, United Kingdom.

Professor Gregory Challis

My global research connections, partners and funding can be viewed on my Monash Research Profile.

Click the links below to connect with me on Twitter, ORCID and Google Scholar.

Our research

Our lab is focused on the discovery of novel antibiotics, anticancer agents and other bioactive natural products from bacteria. We use a combination of molecular genetics, enzymology, structural biology, organic synthesis and analytical chemistry to elucidate the biosynthetic pathways and mechanisms of action of the molecules we discover. Knowledge generated by the biosynthetic studies is exploited for pathway engineering to create novel natural product analogues with enhanced therapeutic potential.

Lab members

We are committed to excellence in research.


View our chosen highlighted key publications.

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We want to share our research discoveries & successes with you.

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Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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