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Challis lab publications

Selected highlight publications

1. S. Kosol, A. Gallo, D. Griffiths, T.R. Valentic, J. Masschelein, M. Jenner, E.L. de los Santos, L. Manzi, P.K. Sydor, D. Rea, S. Zhou, V. Fülöp, N.J. Oldham, S.-C. Tsai, G.L.Challis, and J.R. Lewandowski. Structural basis for chain release from the enacyloxin polyketide synthase. Nat. Chem. 2019, 11, DOI: 10.1038/s41557-019-0335-5.

2. J. Masschelein, P.K. Sydor, C. Hobson, R. Howe, C. Jones, D.M. Roberts, Z.L. Yap, J. Parkhill, E. Mahenthiralingam and G.L. Challis. A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis. Nat. Chem. 2019, 11, DOI: 10.1038/s41557-019-0309-7.

3. L.M. Alkhalaf, S.M. Barry, D. Rea, A. Gallo, D. Griffths, J.R. Lewandoswki, V. Fülöp and G.L. Challis. Binding of distinct substrate conformations enables hydroxylation of remote sites in thaxtomin D by cytochrome P450 TxtC. J. Am. Chem. Soc. 2019, 141, 216-222.

4. M. Jenner, S. Kosol , D. Griffiths, P. Prasongpholchai, L. Manzi, A.S. Barrow, J.E. Moses, N.J. Oldham, J.R. Lewandowski and G.L. Challis. Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases. Nat. Chem. Biol. 2018, 14, 270-275.

5. L. Song, M. Jenner, J. Masschelein, C. Jones, M. Bull, S. Harris, R. Hartkoorn, A. Vocat, I. Romero-Canelón, P. Coupland, Paul, G. Webster, M. Dunn, R. Weiser, C. Paisey, S. Cole, J. Parkhill, E. Mahenthiralingam and G.L. Challis. Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. J. Am. Chem. Soc. 2017, 139, 7974-7981.

Additional publications

A full list of Challis Lab publications can be viewed on PubMed.