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Challis Lab research

CollaborationsStudent research projects | Publications

About Professor Greg Challis

Greg Challis is the Monash-Warwick Alliance Professor of Sustainable Chemistry (Chemical and Synthetic Biology), a joint position between the Department of Biochemistry and Molecular Biology at Monash University and the Department of Chemistry at the University of Warwick in the UK.

He graduated with a BSc in Chemistry (1994) from Imperial College London and a DPhil in Organic Chemistry (1998) from the University of Oxford, for research carried out under the supervision of Prof. Sir Jack Baldwin FRS. He carried out postdoctoral research as a Wellcome Trust International Prize Travelling Research Fellow in the Department of Chemistry at Johns Hopkins University, USA, with Prof Craig Townsend (1998-2000) and in the Department of Genetics at John Innes Centre, UK, with Prof Keith Chater FRS (2000-2001). In 2001, he took up a lectureship in Chemical Biology in the Department of Chemistry at the University of Warwick. In 2003 he was promoted to Senior Lecturer and in 2006 he was promoted to Professor.

His research has been recognised by numerous awards, including the Gabor Medal (2009) and a Wolfson Research Merit Award (2013-2018) from the Royal Society, the 2017 Interdiscplinary Prize and 2009 Hickinbottom Award of the Royal Society of Chemistry, the 2007 Fleming Prize Lecture of the Society for General Microbiology, the 2007 Wain Medal Lecture of the University of Kent, the 2002 Meldola Medal and Prize of the Royal Society of Chemistry and the 1998 GlaxoWellcome Postdoctoral Fellowship. In 2011, he was elected as a Fellow of the Royal Society of Chemistry (FRSC) and a Fellow of the Royal Society of Biology (FRSB).

Our research

Current projects

  1. Structural basis for regulation of antibiotic biosynthesis by actinobacterial hormones
  2. Structural studies of trans-AT polyketide synthases
  3. Molecular mechanism of enantiodivergent biocatalysis of biosynthetic Diels-Alder reactions

Research activities

Our main focus is currently structural studies of biosynthetic enzymes and transcriptional regulators of biosynthetic pathway expression.


We employ a combination of X-ray crystallography and single particle cryo-electron microscopy to determine the structures of proteins and protein-DNA complexes.


We collaborate with many scientists and research organisations around the world. Some of our more significant national and international collaborators are listed below. Click on the map to see the details for each of these collaborators (dive into specific publications and outputs by clicking on the dots).

Associate Professor Max Cryle, Monash Biomedicine Discovery Institute and EMBL Australia Group Leader (Victorian Node)

Student research projects

The Challis Lab offers a variety of Honours, Masters and PhD projects for students interested in joining our group. There are also a number of short-term research opportunities available. You are encouraged to contact Professor Greg Challis regarding potential projects that align with the presented research themes.