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La Gruta Laboratory

CD8+ T Cell Immunity and Ageing

Welcome to the La Gruta Lab

My laboratory investigates the key extrinsic and intrinsic factors regulating effective T cell development, activation, and immune responses, and how these are perturbed in the elderly.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Immunity Program and a member of the Department of Biochemistry and Molecular Biology.

Professor Nicole La Gruta

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on, ORCID and Google Scholar.

Our research

CD8+ T cell immunity is critical for the effective elimination of viruses and control of tumours. Our research uses advanced cellular and molecular approaches to interrogate the key drivers of effective CD8+ T cell responses. Our lab uses a wide range of molecular and cellular techniques to understand these drivers so that they may be exploited to confer optimal immunity, as well as understanding how they go awry in the elderly or in autoimmune conditions, ultimately allowing us to target these factors in a clinical context.

  • T cell receptor/peptide-MHCI interactions and consequences for T cell activation

  • Intrinsic CD8+ T cell dysfunction in the elderly

  • The impact of T cell development on naïve CD8+ T cells

Lab members

We are committed to excellence in research.


View our chosen highlighted key publications.

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We want to share our research discoveries & successes with you.

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Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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