La Gruta lab publications

Selected highlight publications

(* joint first or corresponding authors)

1. Zareie P, Szeto C, Farenc C, Gunasinghe SD, Kolawole EM, Nguyen A, Blyth C, Sng XYX, Li J, Jones CM, Fulcher AJ, Jacobs JR, Wei Q, Wojciech L, Petersen J, Gascoigne NRJ, Evavold BD, Gaus K, Gras S*, Rossjohn J*, La Gruta NL*. Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling. Science. 2021 Jun 4;372(6546):eabe9124. Abstract |  Reprint |  Full text

2. Lim JJ*, Jones CM*, Loh TJ, Ting YT, Zareie P, Loh KL, Felix NJ, Suri A, McKinnon M, Stevenaert F, Sharma RK, Klareskog L, Malmström V, Baker DG, Purcell AW, Reid HH*, La Gruta NL*, Rossjohn J*. The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR. Sci Immunol. 2021 Apr 16;6(58):eabe0896.

3. Quinn KM, Hussain T, Kraus F, Formosa LE, Lam WK, Dagley MJ, Saunders EC, Assmus LM, Wynne-Jones E, Loh L, van de Sandt CE, Cooper L, Good-Jacobson KL, Kedzierska K, Mackay LK, McConville MJ, Ramm G, Ryan MT, La Gruta NL. Metabolic characteristics of CD8⁺ T cell subsets in young and aged individuals are not predictive of functionality. Nat Commun. 2020 Jun 5;11(1):2857.

4. Wu T*, Guan J*, Handel A, Tscharke DC, Sidney J, Sette A, Wakim LM, Sng XYX, Thomas PG, Croft NP*, Purcell AW*, La Gruta NL*. Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses. Nat Commun. 2019 Jun 28;10(1):2846.

5. Quinn KM, Fox A, Harland KL, Russ BE, Li J, Nguyen THO, Loh L, Olshanksy M, Naeem H, Tsyganov K, Wiede F, Webster R, Blyth C, Sng XYX, Tiganis T, Powell D, Doherty PC, Turner SJ, Kedzierska K, La Gruta NL. Age-Related Decline in Primary CD8⁺ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8⁺ T Cells. Cell Rep. 2018 Jun 19;23(12):3512-3524.

6. Gras S, Chadderton J, Del Campo CM, Farenc C, Wiede F, Josephs TM, Sng XYX, Mirams M, Watson KA, Tiganis T, Quinn KM, Rossjohn J, La Gruta NL. Reversed T cell receptor docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response. Immunity. 2016 Oct 18; 45:749-760.

Additional publications

A full list of La Gruta Lab publications can be viewed on PubMed.