Mifsud Laboratory
Clinical Immunology
Welcome to the Mifsud Lab
Our laboratory explores how T cell mediated immune responses contribute to the onset or perpetuation of human disorders (e.g. autoimmunity, allergy) and transplant rejection. A major focus is examining how virus-specific T cells cross-react toward either self or non-self human leukocyte antigen (HLA)/peptide complexes and how this mechanism induces adverse immune responses.
We're part of the Monash Biomedicine Discovery Institute, and a member of the Infection & Immunity Program and the Department of Biochemistry and Molecular Biology.
Dr Nicole Mifsud
My global research connections, partners and funding can be viewed on my Monash Research Profile.
If you are a student interested in doing research in our lab, visit Supervisor Connect.
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Our research
We use a multidisciplinary approach for (i) characterisation of T cells that drive susceptibility to human disorders (e.g. transplant rejection, drug hypersensitivity and autoimmunity) via inappropriate immune responses or (ii) identification of T cell epitopes for immunotherapeutic development (e.g. cancer). These approaches include cellular immunology (T cell lines/clones, combinatorial peptide libraries, flow cytometry), proteomics (mass spectrometry), CRISPR/Cas 9 gene editing, next generation sequencing (DNA-seq, RNA-seq), molecular biology and structural biology (crystallography). Our focus areas:
Lab members
We are committed to excellence in research.
Join Our Lab
We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.