Current research

2023 key articles

Predictors of early mobilization in patients requiring VV ECMO for greater than 7 days: An international cohort study.
Tonna JE, Bailey M, Abrams D, Brodie D, Hodgson CL.
Heart & Lung. 2023 Jun 10;62:57-63. doi: 10.1016/j.hrtlng.2023.05.022. Epub ahead of print.

Psychometric properties of health-related quality of life instruments used in survivors of critical illness: a systematic review.
De Silva S, Chan N, Esposito K, Higgins AM, Hodgson CL.
Quality of Life Research. 2023 Aug 2. doi: 10.1007/s11136-023-03487-x. Epub ahead of print.

Long COVID-unravelling a complex condition.
Hodgson CL, Broadley T.
The Lancet Respiratory Medicine. 2023 Aug;11(8):667-668. doi: 10.1016/S2213-2600(23)00232-1. Epub 2023 Jul 17.

ECMO PAL: Survival Prediction in Venoarterial Extracorporeal Membrane Oxygenation using Deep Neural Networks.
Šeman M, Stephens A, Diehl A, Pilcher D, Barbaro RP, Brodie D, Pellegrino V, Kaye DM, Gregory SD, Hodgson C.
Heart, Lung and Circulation. 2023 Jul;32(3):S112-S113. doi: 10.1016/j.hlc.2023.06.730.

Development of a performance standard for physiotherapists delivering exercise and mobilisation to the critically ill: A modified Delphi consensus study.
Lang JK, Haines KJ, Hodgson CL.
Australian Critical Care. 2023 Jul;36(4):470-476. doi: 10.1016/j.aucc.2022.07.003. Epub 2022 Sep 10.

Correlation of patient-reported outcome measures to performance-based function in critical care survivors: PREDICTABLE.
Paton M, Lane R, Paul E, Linke N, Shehabi Y, Hodgson CL.
Australian Critical Care. 2023 Jul;36(4):485-491. doi: 10.1016/j.aucc.2022.05.006. Epub 2022 Jul 7.

To mobilise or not to mobilise: is that the right question?
Hodgson CL, Kho ME, da Silva VM.
Intensive Care Medicine. 2023 Aug;49(8):1000-1004. doi: 10.1007/s00134-023-07088-7. Epub 2023 May 9.

Extracorporeal Membrane Oxygenation Practice Changes in Australian Adult Intensive Care Units From 2018 to 2022.
Hodgson C, Linke N, Fulcher B, Anderson S, Bailey M, Bernard S, Board J, Brodie D, Buhr H, Burrell A, Cooper D, Fan E, Fraser J, Gattas D, Higgins A, Hopper I, Huckson S, Litton E, McGuinness S, Nair P, Orford N, Parke R, Pellegrino V, Pilcher D, Sheldrake J, Reddi B, Stub D, Trapani T, Udy A, Serpa Neto A, EXCEL Investigators, International ECMO Network.
A46 ECMO, ARDS, AND ACUTE RESPIRATORY FAILURE. Thematic Poster Session. 2023 May 21. A1720-A1720. doi: 10.1164/ajrccm-conference.2023.207.1_MeetingAbstracts.A1720.

Early Active Mobilization during Mechanical Ventilation in the ICU. Reply.
Hodgson CL, Bailey M, Young PJ; TEAM Study Investigators.
The New England Journal of Medicine. 2023 Feb 9;388(6):573-574. doi: 10.1056/NEJMc2216086. PMID: 36780686.

Extracorporeal membrane oxygenation and Extracorporeal Membrane Oxygenation Cardiopulmonary Resusciation (ECPR) research priorities in Australia: A clinician survey.
Dennis M, Southwood TJ, Oliver M, Nichol A, Burrell A, Hodgson C.
Australian Critical Care. 2023 Sep;36(5):828-831. doi: 10.1016/j.aucc.2022.11.009. Epub 2023 Jan 4. PMID: 36604268.

The effect of mobilization at 6 months after critical illness — meta-analysis
Paton M, Chan S, Tipping CJ, Stratton A, Serpa Neto A, Lane R, Young PJ, Romero L, Broadley T, Hodgson CL.
NEJM Evidence. 2023 Dec;2(2). doi: 10.1056/EVIDoa2200234.

Clinimetrics: The Lawton-Brody Instrumental Activities of Daily Living Scale.
Wei L, Hodgson C.
Journal of Physiotherapy. 2023 Jan;69(1):57. doi: 10.1016/j.jphys.2022.06.007. Epub 2022 Dec 15.

Nursing workforce, education, and training challenges to implementing extracorporeal membrane oxygenation services in Australian intensive care units: A qualitative substudy.
Ross P, Watterson J, Fulcher BJ, Linke NJ, Nicholson AJ, Ilic D, Hodgson CL.
Australian Critical Care. 2023 Jan;36(1):114-118. doi: 10.1016/j.aucc.2021.12.003. Epub 2022 Jan 10.

Cost-effectiveness of a purpose-built ward environment and new allied health model of care for major trauma.
Gabbe BJ, Reeder S, Ekegren CL, Mather A, Kimmel L, Cameron PA, Higgins AM.
The Journal of Trauma and Acute Care Surgery. 2023 Jun 1;94(6):831-838. doi: 10.1097/TA.0000000000003950. Epub 2023 Mar 7.

Early versus late tracheostomy: what do patients want?
Sutt AL, Fraser JF.
Critical Care. 2023 Apr 19;27(1):151. doi: 10.1186/s13054-023-04443-4.

Interleukin-6 inhibitors in non-COVID-19 ARDS: analyzing the past to step into the post-COVID-19 era.
Gandini L, Fior G, Schibler A, Obonyo NG, Li Bassi G, Suen JY, Fraser JF.
Critical Care. 2023 Mar 25;27(1):124. doi: 10.1186/s13054-023-04394-w.

Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping review.
Ijuin S, Liu K, Gill D, Kyun Ro S, Vukovic J, Ishihara S, Belohlavek J, Li Bassi G, Suen JY, Fraser JF.
Resuscitation Plus. 2023 Jul 14;15:100426. doi: 10.1016/j.resplu.2023.100426.

Effects of transfusing older red blood cells and platelets on obstetric patient outcomes: A retrospective cohort study.
Obonyo NG, Lu LY, White NM, Sela DP, Rachakonda RH, Teo D, Tunbridge M, Sim B, See Hoe LE, Fanning JP, Tung JP, McKnoulty M, Bassi GL, Suen JY, Fraser JF.
International Journal of Gynecology & Obstetrics. 2023 Jul 20. doi: 10.1002/ijgo.14997. Epub ahead of print.

A systematic review and meta-analysis on endothelial dysfunction post-shock resuscitation.
Obonyo N, Sela D, Raman S, Rachakonda R, Schneider B, Hoe LS, Fanning J, Bassi GL, Maitland K, Suen J, Fraser J.
Research Square. 2023 Jul 5. doi: 10.21203/rs.3.rs-2917670/v1. Preprint.

The effects of nitric oxide on coagulation and inflammation in ex vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass.
Malfertheiner MV, Garrett A, Passmore M, Haymet AB, Webb RI, Von Bahr V, Millar JE, Schneider BA, Obonyo NG, Black D, Bouquet M, Bartnikowski N, Suen JY, Fraser JF.
Artificial Organs. 2023 Jul 3. doi: 10.1111/aor.14608. Epub ahead of print.

A Novel Speckle-Tracking Echocardiographic Parameter Assessing Left Ventricular Loading During VA ECMO in a Pre-clinical Model of Cardiogenic Shock.
Sato K, Heinsar S, Obonyo N, Wildi K, Liu K, Farah S, Ainola C, Sato N, Ijuin S, Kyun Ro S, Fior G, Gandini L, Bouquet M, Wilson E, Passmore M, Hyslop K, Chan J, Platts D, Scalia G, Suen J, Li Bassi G, Fraser J.  
Heart, Lung and Circulation. 2023 Jul;32(3):S406. doi: 10.1016/j.hlc.2023.06.562.

Effects of Red Blood Cell Transfusion on Patients Undergoing Cardiac Surgery in Queensland—A Retrospective Cohort Study.
Dhanapathy V, Obonyo N, White N, Sela D, Rachakonda R, Tunbridge M, Sim B, Teo D, See Hoe L, Fanning J, Tung J, Suen J, Fraser.
Heart, Lung and Circulation. 2023 Jul;32(3):S321. doi: 10.1016/j.hlc.2023.06.458.

Assessment and diagnosis of right ventricular failure-retrospection and future directions.
Ro SK, Sato K, Ijuin S, Sela D, Fior G, Heinsar S, Kim JY, Chan J, Nonaka H, Lin ACW, Bassi GL, Platts DG, Obonyo NG, Suen JY, Fraser JF.
Frontiers in Cardiovascular Medicine. 2023 May 30;10:1030864. doi: 10.3389/fcvm.2023.1030864.

Resuscitation Associated Endotheliopathy.
Obonyo NG, Sela DP, Raman S, Reema R, Bailey S, Hoe LES, Fanning JP, Bassi GL, Maitland K, Suen JY, Fraser JF.
searchRxiv. CABI. 2023 May 9. doi: 10.1079/searchrxiv.2023.00206.

Proposal of a reliable scoring system for the histological assessment of multiorgan injury in large animal models of ischaemia and shock.
Palmieri C, Hoe LS, Dyer W, Heinsar S, Rozencwaig S, Tung JP, Bartnikowski N, Passmore M, Bouquet M, Hislop K, Wilson E, Li Bassi G, Mcgiffin D, Suen J, Fraser J.
Journal of Comparative Pathology. 2023 May;203:57-58. doi: 10.1016/j.jcpa.2023.03.059.

Donor heart ischemic time can be extended beyond 9 hours using hypothermic machine perfusion in sheep.
See Hoe LE, Li Bassi G, Wildi K, Passmore MR, Bouquet M, Sato K, Heinsar S, Ainola C, Bartnikowski N, Wilson ES, Hyslop K, Skeggs K, Obonyo NG, Shuker T, Bradbury L, Palmieri C, Engkilde-Pedersen S, McDonald C, Colombo SM, Wells MA, Reid JD, O'Neill H, Livingstone S, Abbate G, Haymet A, Jung JS, Sato N, James L, He T, White N, Redd MA, Millar JE, Malfertheiner MV, Molenaar P, Platts D, Chan J, Suen JY, McGiffin DC, Fraser JF.
The Journal of Heart and Lung Transplantation. 2023 Aug;42(8):1015-1029. doi: 10.1016/j.healun.2023.03.020. Epub 2023 Apr 7.

Preclinical Studies on Pulsatile Veno-Arterial Extracorporeal Membrane Oxygenation: A Systematic Review.
Kanagarajan D, Heinsar S, Gandini L, Suen JY, Dau VT, Pauls J, Fraser JF.
ASAIO J. 2023 May 1;69(5):e167-e180. doi: 10.1097/MAT.0000000000001922. Epub 2023 Mar 27.

Extracorporeal Circulation-Related Immune Response.
Ki KK, Heinsar S, Langguth D, Fraser JF.
In: Molnar Z, Ostermann M, Shankar-Hari M (eds) Management of Dysregulated Immune Response in the Critically Ill. Lessons from the ICU. Springer, Cham. 2023. doi: 10.1007/978-3-031-17572-5_5 .

Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation.
Rozencwajg S, Heinsar S, Wildi K, Jung JS, Colombo SM, Palmieri C, Sato K, Ainola C, Wang X, Abbate G, Sato N, Dyer WB, Livingstone S, Helms L, Bartnikowski N, Bouquet M, Passmore MR, Hyslop K, Vidal B, Reid JD, McGuire D, Wilson ES, Rätsep I, Lorusso R, Schmidt M, Suen JY, Bassi GL, Fraser JF.
Scientific Reports. 2023 Mar 10;13(1):4002. doi: 10.1038/s41598-023-30226-6.

A NOVEL SPECKLE-TRACKING ECHOCARDIOGRAPHIC PARAMETER CONSIDERING LEFT VENTRICULAR LOADING CONDITION IN CARDIOGENIC SHOCK DURING VA ECMO.
Sato K, Heinsar S, Wildi KS, Obonyo N, Liu K, Farah S, Ainola C, Sato N, Fior G, Ro SK, Gandini L, Ijuin S, Bouquet M, Wilson E, Passmore M, Hyslop K, Chan JH, Platts D, Suen J, Li Bassi G, Fraser J.
Journal of the American College of Cardiology. 2023 Mar;81(8_Supplement):1396. doi: 10.1016/S0735-1097(23)01840-5.

Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage.
Kulasinghe A, Liu N, Tan CW, Monkman J, Sinclair JE, Bhuva DD, Godbolt D, Pan L, Nam A, Sadeghirad H, Sato K, Bassi GL, O'Byrne K, Hartmann C, Dos Santos Miggiolaro AFR, Marques GL, Moura LZ, Richard D, Adams M, de Noronha L, Baena CP, Suen JY, Arora R, Belz GT, Short KR, Davis MJ, Guimaraes FS, Fraser JF.
Immunology. 2023 Mar;168(3):403-419. doi: 10.1111/imm.13577. Epub 2022 Sep 27.