Project
About this study
This study will examine immune response to vaccination and infection across humoral immunity (antibodies, B cells) and cellular immunity (T cells) in children and adults with underlying health conditions including chronic kidney disease, lung disease, immune deficiencies, immunosuppressive treatments, and stem and solid organ transplant recipients. Through this study, we hope to guide the future development of improved vaccination and treatment strategies for those most at risk of severe COVID-19.
Join the PROPHECY Study
By contacting PROPHECY study you are providing consent to receive further information.
Eligibility
The PROPHECY study encompasses a number of different cohorts (see below) based in Melbourne, Victoria.
If you fall into any of these health categories we recommend that you contact your medical provider or specialist about joining the study.
We are also looking for healthy controls, healthy subjects will be used to set the baseline for the expected immune response to the COVID-19 vaccines in people who do not have compromised immune systems.
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Kidney Disease & Transplant
Chronic Kidney Disease
- Adults 18+ years old
- On haemodialysis and on renal transplant waiting list
- Recruited from the Monash Health Services
Kidney transplant recipients
- Paediatrics (5-17 years old) & Adults 18+ years old
- Adults recruited from the Monash Health Services
- Paediatrics recruited from Monash Health Services & MCRI at the Royal Children’s Hospital
Lung disease and transplants
- Chronic obstructive pulmonary disease (COPD), Interstitial lung disease (ILD) & Lung transplant patients
- Adults 18 + years old
- Recruited from the Alfred Respiratory Medicine Clinic
People Living with HIV
- 18 + years old
- Receiving antiretroviral therapy
- With a viral load <50 copies/ml & CD4+ T cell count >250 cell/µl
- Recruited from the Alfred Health Clinics
Splenectomy
- Adults 18 + years old
- Splenectomy as a consequence of trauma or got other non-malignant conditions for which they do not require ongoing immunosuppressive therapy
- Recruited from the Spleen Australia Registry & Monash Health Services
Primary Immunodeficiency (PID)
- Adults 18 + years old
- Diagnosed with PID
- Those with secondary causes of disease are excluded from this study
- Recruited from the Alfred Health Clinics, Monash Health Services and Eastern Health
Rheumatic disease
- Paediatrics (5-17 years old) & Adults 18+ years old
- Participants being treated for systemic rheumatic diseases
- Adults recruited from the Monash Health Service
- Paediatrics recruited from Monash Health Services & MCRI at the Royal Children’s Hospital
Inflammatory Bowel disease (IBD)
- Paediatrics (5-17 years old) & Adults 18+ years old
- Well managed disease
- Ongoing combination treatment with general immune-suppression and anti-TNF
- Adults recruited from the Alfred Health Clinics
- Paediatrics recruited from Monash Health Services & MCRI at the Royal Children’s Hospital
Post HSCT
- Adults 18+ years old
- Undergone haematopoietic stem cell transplant for haematological malignancy
- Will have their COVID-19 vaccinations within 3-6months post-transplant
- Recruited from the Alfred Health Clinics
About participating
Participation in this study will involve a small sample of blood being taken from a vein in your arm on visits to the hospital. If you are a patient in the cohorts involved in this study these blood samples will coincide with routine blood tests, otherwise we will ask you to attend one of our sites at your scheduled time. Blood collection should take between 10-15 minutes.
Blood will be collected before vaccination and then again at 1 and 6 months after receiving the COVID-19 vaccine/booster. Data will be collected from your medical records and will be given a code to ensure your privacy. This study has been designed to make sure the researchers interpret the results in a fair and appropriate way and avoids study doctors or participants jumping to conclusions.
Participation in this research is voluntary. There are no costs associated with participating in this research project, nor will you be paid.