Characterisation

Isolation and Identification of Impurities, Metabolites, and Degradants:

  • Support in isolating and identifying chemical impurities, degradants, and contaminants.
  • Use of preparative methods like flash chromatography and structure elucidation tools such as NMR, GC-MS, and LC-MS.
  • Simulation of degradation pathways and reactive packaging by-products.

Additional Analytical Services:

  • Structure Elucidation: Using Raman, 1H- and 13C-NMR.
  • Chromatographic Analysis: Including flash chromatography, gas, and liquid chromatography.
  • Spectroscopical Analysis: Using NIR, UV, MALDI-TOF MS, and TOF MS with BSI and APCI.

Morphological and Porosity Analysis

  • Purification of compounds and APIs from synthesis processes and phytochemicals.
  • Imaging techniques for surface structure analysis using optical microscopy, birefringence microscopy, and FTIR.
  • Particle size and shape characterisation using Malvern Morphologi G3, mastersizer and scanning electron microscopy.
  • Adsorption data analysis using nitrogen sorption (BET method) and dynamic vapour sorption (DVS).

Spray-Dried Powders, Nebulisers, and Dry Powder Inhalers:

  • Spray-drying of small peptides and other compounds
  • Characterisation of plume geometry delivered dose, and particle size distribution using impactors
  • Laser diffraction based analysis for powders (mastersizer) and droplets (Spraytec)
  • Assessment of powder rheology and flow properties using FT4
  • Performance characterisation of aerosols and nebulisers.

Characterisation of Impurities and Unknowns:

  • Purification and structural elucidation of impurities, metabolites, and unknowns using chromatographic techniques and NMR.
  • Establishment of modification pathways using solution-based 1H- and 13C-NMR and two-dimensional techniques.
  • Forensic tracking of contaminants and differentiation of naturally derived antioxidants from synthetic analogues.

Purification of Pharmaceutical Ingredients and Natural Products:

  • Conventional distillation, sublimation, liquid-liquid and solid sorbent-based techniques, Biotage flash chromatography, and HPLC.
  • Separation of complex mixtures, isolation of impurities, and development of methods for natural compound separation using normal and reversed-phase chromatography.
  • Scale-up production, recovery of volatiles, stripping degradation products, synthesis by-products, coloured materials, plant pigments, and separation of isomers.

Synthesis and Isolation of Related Compounds:

  • Chemical synthesis and modification of APIs.
  • Purification of precursors or phytochemicals from plant sources.
  • Generation of impurity and metabolite standards.
  • Conducting electrochemically mediated reactions with an ANTEC ROXY Potentiostat.

Analysis of Thermal Properties:

  • Analysis of thermal behaviour of materials associated with polymorphs.
  • Interaction analysis of excipients and active ingredients.
  • Measurement of heat changes and thermal process reversibility using differential scanning calorimetry (DSC) and differential thermal gravimetry (DTG).