Structure-activity relationship (SAR) study designs

Structure-Activity Relationship (SAR) is perhaps the most important concept in drug development.

Medicinal chemists can “read” SAR like a travel guide.

Establishing SAR informs precisely those positions on a molecule where one can modify, to improve certain properties, including:

  • solubility
  • potency
  • selectivity
  • metabolic stability
  • permeability
  • toxicity
  • pharmacokinetics
  • tissue distribution
  • in vivo efficacy

and distinguish these positions from others, where one cannot undertake such modifications.