Expertise and capabilities

The Australian Translational Medicinal Chemistry Facility (ATMCF) provides nationally accessible medicinal chemistry and drug discovery expertise to help transform promising biological discoveries into therapeutic candidates.

Working collaboratively with researchers, medical research institutes, biotechnology companies and translational funding programs, we support the progression of projects from early-stage discovery through to preclinical development and commercial opportunities.

Our multidisciplinary team combines medicinal chemistry, computational drug design and translational expertise to optimise compounds and overcome key challenges in drug development. Through a collaborative model, we help researchers design better drug candidates with improved potency, selectivity, safety and developability, accelerating the path towards new medicines.

Key capabilities include:

  • Medicinal chemistry and lead optimisation
  • Hit validation, triage and progression
  • Structure-activity relationship (SAR) development
  • Structure-based drug design and computational modelling
  • AI-enabled and data-driven drug discovery approaches
  • Intellectual property strategy and patent support
  • Project leadership and translational planning
  • Drug discovery data management and digital platforms
ATMCF works across a broad range of therapeutic areas, including cancer, cardiovascular disease, neurological disorders, inflammatory diseases, infectious and neglected diseases, rare diseases, and diagnostic imaging. We work closely with complementary drug discovery capabilities, including the Centre for Drug Candidate Optimisation (CDCO), as well as screening, fragment-based discovery and translational research platforms, to provide an integrated pathway for therapeutic development. By combining our expertise with these partner capabilities, ATMCF helps bridge the gap between biological research and therapeutic development, playing a critical role in advancing Australia's next generation of medicines.

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