Automated cell manipulation
This project aims to investigate fundamental problems associated with precision manipulation, handling, and automated surgeries on biological cells. This includes studies of cell immobilisation, and modelling of key interactions such as cell deformations and penetration. The outcomes of this project are expected to lead to breakthroughs and the development of novel techniques for automated cell manipulation and microsurgical tasks.
Cell micro-manipulation research is a key research program within the RMRL, which includes: design, analysis and control of micro manipulators, immobilisation of biological cells through micropipette or micro gripper platforms, modelling and characterisation of cell deformation under imposed indentation forces, real-time vision-based cell tracking and deformation modelling, and automation and control of manipulation procedures.
The RMRL possesses advanced facilities to carry out this research, including multi-DOF stepper driven micro manipulation mechanisms, cell aspiration equipment, a laser-based confocal microscope and AFM for imaging of interactions, compound/inverted microscopes capable of digital image acquisition, precision load cells, and laser-based measurement equipment.