Publications

Recent highlights

Saha, S., Corben, L. A., Selvadurai, L. P., Harding, I. H., Georgiou-Karistianis, N. (2025). Predictive machine learning and multimodal data to develop highly sensitive, composite biomarkers of disease progression in Friedreich Ataxia. Scientific Reports, 15, Article 17629.
https://doi.org/10.1038/s41598-025-01047-6

Georgiou‐Karistianis, N., Corben, L. A., Lock, E. F., Bujalka, H., Adanyeguh, I., Corti, M., ... & Henry, P. G. (2025). Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the TRACK‐FA Study. Annals of Neurology.
https://doi.org/10.1002/ana.27237

Huynh, K., Jamadar, S. D., Lampit, A., Siddiqui, M. N., Stout, J. C., & Georgiou-Karistianis, N. (2025). Feasibility and effects of cognitive training on cognition and psychosocial function in Huntington’s disease: A randomised pilot trial. Journal of Neurology, 272, Article 159.
https://doi.org/10.1007/s00415-024-12855-7

Abeyasinghe, P. M., Cole, J. H., Razi, A., Poudel, G. R., Paulsen, J. S., Tabrizi, S. J., Long, J. D., & Georgiou-Karistianis, N. (2025). Brain age as a new measure of disease stratification in Huntington’s Disease. Movement Disorders.
https://doi.org/10.1002/mds.30109

Huynh, K., Jamadar, S., Stout, J., Voigt, K., Lampit, A., & Georgiou-Karistianis, N. (2024). Effects and mechanisms of computerized cognitive training in Huntington’s disease: protocol for a pilot study. Neurodegenerative Disease Management, 1–14.
https://doi.org/10.2217/nmt-2023-0001

Huynh K, Georgiou-Karistianis N, Lampit A, Siddiqui MN, Stout JC, Jamadar SD. Computerized Cognitive Training Increases Gray Matter Volumes in Huntington's Disease: A Pilot Study. Mov Disord. 2024 Aug 9. doi: 10.1002/mds.29972. Epub ahead of print. PMID: 39120126.

Ghofrani-Jahromi M, Poudel GR, Razi A, Abeyasinghe PM, Paulsen JS, Tabrizi SJ, Saha S, Georgiou-Karistianis N. Prognostic enrichment for early-stage Huntington's disease: An explainable machine learning approach for clinical trial. Neuroimage Clin. 2024 Aug 10;43:103650. doi: 10.1016/j.nicl.2024.103650. Epub ahead of print. PMID: 39142216.

Huynh, Katharine, Leila Nategh, Sharna Jamadar, Julie Stout, Nellie Georgiou-Karistianis, and Amit Lampit. "Cognition-oriented treatments and physical exercise on cognitive function in Huntington’s disease: a systematic review." Journal of Neurology 270, no. 4 (2023) Impact factor: 6.0
https://doi.org/10.1007/s00415-022-11516-x

Georgiou-Karistianis N, Corben LA, Reetz K, Adanyeguh IM, Corti M, Deelchand DK, Delatycki MB, Dogan I, Evans R, Farmer J, França MC, Gaetz W, Harding IH, Harris KS, Hersch S, Joules R, Joers JJ, Krishnan ML, Lax M, Lock EF, Lynch D, Mareci T, Muthuhetti Gamage S, Pandolfo M, Papoutsi M, Rezende TJR, Roberts TPL, Rosenberg JT, Romanzetti S, Schulz JB, Schilling T, Schwarz AJ, Subramony S, Yao B, Zicha S, Lenglet C, Henry PG. A natural history study to track brain and spinal cord changes in individuals with Friedreich's ataxia: TRACK-FA study protocol. PLoS One. 2022 Nov 21;17(11):e0269649. doi: 10.1371/journal.pone.0269649. PMID: 36410013; PMCID: PMC9678384.
https://doi.org/10.1371/journal.pone.0269649

Tan B., Shishegar R., Oldham S., Fornito A., Poudel G. and Georgiou-Karistianis N., (2022). Investigating longitudinal changes to frontal cortico-striatal tracts in Huntington’s disease: the IMAGE-HD study. Brain Imaging and Behavior. Published online 29 June 2022. Impact factor: 3.97
https://doi.org/10.1007/s11682-022-00699-6

Tan B., Shishegar R., Poudel G., Fornito A. and Georgiou-Karistianis N. (2021). Longitudinal mapping of cortical surface changes in Huntington’s Disease. Brain Imaging and Behavior. 16(3):1381-1391. Impact factor: 3.43.
https://doi.org/10.1007/s11682-021-00625-2

Abeyasinghe, P.M., Long, J.D., Razi, A., Pustina, D., Paulsen, J.S., Tabrizi, S.J., Poudel, G.R., Georgiou-Karistianis, N. (2021). Tracking Huntington’s disease progression using motor, functional, cognitive and imaging markers. Movement Disorders. Accepted. Impact factor 8.679.
https://doi.org/10.1002/mds.28650

Tan B., Shishegar R., Poudel G., Fornito A., Georgiou-Karistianis N., (2020). Cortical Morphometry and Neural Dysfunction in Huntington's Disease: A Review. European Journal of Neurology. DOI: 10.1111/ene.14648. Impact factor 3.956.
https://doi.org/10.1111/ene.14648

Soloveva, M. V., Jamadar, S., Hughes, M., Velakoulis, D., Poudel, G., & Georgiou-Karistianis, N. (2020). Brain Compensation during Response Inhibition in Premanifest Huntington's Disease. Brain and Cognition. 141:105560. DOI: 10.1016/j.bandc.2020.105560. Impact factor 2.619.
https://doi.org/10.1016/j.bandc.2020.105560

Shishegar, R., Harding, I.H., Corben, L.A., Delatycki, M,B., Storey, E., Egan, G.F., & Georgiou-Karistianis, N (2020). Longitudinal Increases in Cerebral Brain Activation During Working Memory Performance in Friedreich Ataxia: 24-Month Data from IMAGE-FRDA. Cerebellum doi:10.1007/s12311-019-01094-6. Impact factor 3.413.
https://doi.org/10.1007/s12311-019-01094-6

Selvadurai, L. P., Corben, L. A., Delatycki, M. B., Storey, E., Egan, G. F., Georgiou-Karistianis, N., & Harding, I. H. (2020). Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE-FRDA Study. Human Brain Mapping, 1097-0193; DOI: 10.1002/hbm.24921. Impact factor 4.554.
https://doi.org/10.1002/hbm.24921

Soloveva, M.V., Jamadar, S.D., Velakoulis, D., Poudel, G., & Georgiou-Karistianis, N. (2020). Brain Compensation in Premanifest Huntington's Disease. Neuropsychologia, 1873-3514; DOI: 10.1016/j.neuropsychologia.2019.107262. Impact factor 2.872.
https://doi.org/10.1016/j.bandc.2020.105560

Poudel, G., Harding, I., Egan, G., Georgiou-Karistianis, N. (2019). Network spread determines severity of degeneration and disconnection in Huntington's disease. Human Brain Mapping, 40(14), 4192-4201. doi.org/10.1002/hbm.24695. Impact factor 4.927.
https://doi.org/10.1002/hbm.24695

Ward, P., Harding, I., Close, T., Corben, L., Delatycki, M., Storey, E., Georgiou-Karistianis, N., Egan, G. (2019). Longitudinal dentate nuclei iron concentration and atrophy in Friedreich ataxia: IMAGE-FRDA. Movement Disorders, 34, 335-343. doi:10.1002/mds.27606. Impact Factor 8.324.
https://doi.org/10.1002/mds.27606

TRACK-FA Neuroimaging Consortium publications

March, 2025
Georgiou‐Karistianis, N., Corben, L. A., Lock, E. F., Bujalka, H., Adanyeguh, I., Corti, M., ... & Henry, P. G. (2025). Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the TRACK‐FA Study. Annals of Neurology. https://doi.org/10.1002/ana.27237

November, 2022
Georgiou-Karistianis, N., Corben, L. A., Reetz, K., Adanyeguh, I. M., Corti, M., Deelchand, D. K., Delatycki, M. B., Dogan, I., Evans, R., Farmer, J., França, M. C., Gaetz, W., Harding, I. H., Harris, K. S., Hersch, S., Joules, R., Joers, J. J., Krishnan, M. L., Lax, M., Lock, E. F., … Henry, P. G. (2022). A natural history study to track brain and spinal cord changes in individuals with Friedreich's ataxia: TRACK-FA study protocol. PloS one, 17(11), e0269649. https://doi.org/10.1371/journal.pone.0269649