Hagemeyer Group - NanoBiotechnology

Key terms: Molecular Imaging, Drug Delivery, Nanotechnology, Biotechnology

2020 group L-R Back row: Associate Professor Christoph Hagemeyer, Dr Be'eri Niego, Mr Jason Palazzolo, Front Row: Ms Shweta Jagdale, Ms Akshita Rana, Mr Martin Ezeani, Dr Ting-Yi Wang, Ms Jaclyn Lange Absent: Dr Erik Westein, Ms Rania Hashad, Ms Jurie Tashkandi

Research Overview

Our main theme is the development of "bio-better" antibodies with added functionality for the treatment of thrombosis, inflammation, diabetes and cancer. Using specifically modified recombinant antibodies we can deliver small molecules, therapeutic oligos, proteins and nanoparticles with high precision and reduced adverse effects. We can achieve this with a new bio-enzymatic conjugation method allowing site-specific attachment of nano-sized delivery scaffolds without affecting antibody function. We are also active in the molecular imaging area. Using targeted natural nanoparticles, we would like to significantly increase the number of imaging labels per antibody in MRI and PET/SPECT as well as photoacoustic and fluorescence imaging. This can increase the detection limit of current approaches.

Projects and opportunities

• Targeted virus particles for gene therapy
• Antibody drug conjugates for cancer treatment
• Single-chain antibody-targeted nanoparticles for therapy and diagnosis
• Recombinant agents for efficient and safe anticoagulation as well as thrombolysis

For current project opportunity descriptions please visit our Honours page

Publications

See recent publications for Christoph Hagemeyer in the Monash RSS feed immediately below, at Google Scholar 'Christoph Hagemeyer'.

Current Grants

• Monash-Helmholtz Laboratory for Radio-Immuno-Theranostics (MHELTHERA) together with Helmholtz Zentrum Dresden Rossendorf, Germany (2021-2025). Monash Investigators: Egan, Robinson, Paterson, Werrett, Alt, Hagemeyer, Tuck, Andrews, Jupp.
• Plan 111 in collaboration with Shandong University, Ministry of Science and Technology of China (2020-24): Discipline innovation of colloid and interface chemistry. PIs: Caruso, Besenbacher, Tieu, Qiao, De Geest, Lee, Eastoe, Nicolas, Hagemeyer, Thurecht, Ashokkumar.
• NHMRC Ideas Grant APP1181440 (2020-23): Self-regulated, glucose-responsive nanomaterials for smart insulin delivery. PIs: Hagemeyer, Cavalieri.
• Biomedical Translation Bridge Program Grant BTB00064 in collaboration with AdAlta (2020-21): Clinical imaging of CXCR4 in the development of an i-body therapy for idiopathic pulmonary fibrosis. PIs: Foley, Hagemeyer, Egan, Scott, Westall, Donnelly, Alt.
• ARC LIEF Grant LE200100053 (2020): Single Particle Elemental Analysis – Imaging Mass Cytometer Facility. PIs: Ellis, Bush, Mitchell, Corbett, Reichman, Ball, Fox, Nugegoda, Paz Ferreiro, Cook, Hagemeyer, Teo, Yu, Brinkworth, Gray.
• Network of Excellence for Molecular Imaging and Precision Radiopharmaceuticals in collaboration with Helmholtz Zentrum Dresden Rossendorf, Germany and TRIUMF, University of British Columbia, Canada (2019-20). Monash PIs: Egan, Porter, Andrews, Follink, Law, Hagemeyer, Alt.
• NHMRC Senior Research Fellowship APP1154270 (2019-23): Smart targeted nanoparticles for diagnosis and therapy. PI: Hagemeyer
• NHMRC Project Grant APP1138361 (2018-21): Degradable nanocapsules for thromboprophylaxis and treatment of acute thrombosis. PIs: Hagemeyer, Caruso
• NHMRC Project Grant APP1120129 (2017-20): Molecular imaging and therapy of cardiac fibrosis in atrial fibrillation and heart failure. PIs: Hagemeyer, McMullen