El-Osta research group

Key terms: Clinical and Molecular Epigenetics, Chromatin, DNA and RNA methylation, Histones, Transcriptional Regulation, Human Disease, Computational Epigenomics

Links to page content: Research goals | The group | Research overview | Research focus | Projects and opportunities | Publications

Research goals

  1. Understand mechanisms of transcriptional control in metabolic disease
  2. Novel epigenetic discoveries in diabetes and its complications
  3. Set7 as a novel therapeutic target in vascular disease

The group

2021 group. L-R: Mr Jairo Arturo Pinzon Cortes, Ms Mie Jensen, Dr Keith Al-Hasani, Dr Ishant Khurana, Professor Sam El-Osta, Dr Jun Okabe, Dr Scott Maxwell, Dr Harikrishnan Kaipananickal

Group Leader

Research Overview

It is increasingly appreciated that gene-environment interactions particularly as they pertain to human health and disease involve epigenetic pathways including a range of biochemical modifications of chromatin including DNA methylation are key areas of interest. The central focus of my research team is to investigate the mechanisms by which specific epigenetic changes including chromatin modifications serve to integrate the transcriptional responses to distinct signaling pathways. The rapid rate of progress over the past five years and the series of discoveries that we and others have contributed in the field concerning epigenetic modification and gene regulation reflect unheralded advances in understanding human development and disease.

We are interested in characterizing the functional roles of specific components critical in gene regulation and examine the link to human disease using genetic, epigenomic and molecular approaches. The group led by Professor El-Osta is interested in understanding the roles of specific transcriptional components in the regulation of metabolic memory and cardiac disease and further extend our understanding of gene silencing events associated with genomic methylation in pre-clinical models and human populations. The focus of the laboratory is to provide fundamental insights into the mechanisms by which epigenetic changes and associated chromatin modifications control genes implicated in human health and disease.

Our investigation of the molecular mechanisms of gene regulation by specific repressor and co-activator complexes using vascular endothelial and cardiac cells as well as the brain, has led to a range of novel mechanistic insights into the biology of epigenetic changes mediating critical transcriptional changes in models of endothelial dysfunction, vascular disease and in utero programming. Professor El-Osta’s laboratory, has contributed to understanding the molecular mechanisms whereby epigenetic changes exert positive and negative transcriptional functions in specific model systems. His team explores the relationship between different classes of co-repressor and activator complexes and the regulation of chromatin remodeling events in maintaining gene expression implicated in disease.

Research Focus

Projects and Opportunities

Current project funding

Recent publications

Pubmed link [El-Osta+A]. See feed of Monash University validated publications and projects below.