Centre for Inflammatory Diseases
The immune system evolved largely to protect the body from infectious agents. A sophisticated immune system means that humans can fight infection more effectively. However, it also increases the risk malfunctions that cause damaging inflammation. These malfunctions include autoimmune diseases, where the immune system reacts against oneself. Autoimmune diseases affect more than 5% of the population - and other chronic inflammatory diseases are equally important in human health and disease.
Research in The Monash University Centre for Inflammatory Diseases (CID) spans basic experimental biology, clinical research and clinical practice in inflammatory diseases. We use both clinical and laboratory based experimental techniques to explore the mechanisms of inflammatory injury in important human diseases - and then relate these to unmet needs in patient treatment and management. Researchers within the Centre are expert in laboratory based and clinically focused research. Researchers work in critical areas in both infectious diseases and damaging inflammation. Our research is in areas as diverse as the basic biology of health and disease, through to helping people with disease manage their illnesses better and be treated with better and safer treatments.
We work on autoimmune diseases, including vasculitis, glomerulonephritis, systemic lupus erythematosus, Sjögren's Syndrome and rheumatoid arthritis. Causes of liver, kidney and lung scarring and loss of function are a focus, as are how infection and inflammation influence white blood cells and their movements into tissues. At a more basic level, researchers in the theme work on how inflammatory processes may be linked to cancer, as well as the protective and damaging effects of the first responders to infection and inflammation.