Transfusion Research Unit (TRU)
Associate Professor Erica Wood, Professor Peter Cameron, Professor John McNeil
The Transfusion Research Unit (TRU) was established in 2008 to provide a research focus on the use of blood transfusions in different clinical settings, especially in the treatment of rare blood conditions. TRU has developed ongoing collaborations with various state, national and international partners. These include health departments, organisations, and institutions including the Victorian Department of Health and Human Services, the National Blood Authority, Australian Red Cross Blood Service, New Zealand Blood Service and industry partners.
TRU works closely with clinical leaders to establish national clinical quality registries and other projects to collect information about conditions requiring major and/or complex transfusion support, and to better understand and improve outcomes for patients.
Clinical experts from around Australia and New Zealand participate as local investigators and project steering committee members. TRU also has close links with governments, advisory groups, specialty Colleges and professional societies to ensure translation of research into policy and practice.
Current research registries:
- Aplastic Anaemia Registry (AAR)
- Haemaglobinopathies including thalssemia and sickle cell disease (HbR)
- Massive Transfusion Registry (MTR)
- Myeloma and Related Diseases Registry (MRDR)
- Neonatal Alloimmune Thrombocytopenia (NAIT)
- Registry of Kidney Diseases (ROKD)
- Thrombotic Thrombocytopenic Purpura (TTP)
Other projects managed by the TRU:
Registries in development:
- Lymphoma and Related Diseases Registry (LaRDR)
- Myelodysplastic Syndrome (MDS)
Other transfusion projects:
- Data linkage: in collaboration with established large clinical registries (for trauma, intensive care and cardiac surgery) we use data from these sources as well as administrative datasets (such as hospital admissions) and link with laboratory information to develop models to predict and monitor blood use.
- Systematic reviews: in collaboration with Oxford’s Systematic Reviews Initiative team we undertake systematic reviews to better understand the current evidence base for transfusion practice and identify evidence gaps for future research.
- New activities include exploration of the implementation of new national patient blood management guidelines.
Transfusion Outcomes Research Collaborative:
TRU is also the home of the Transfusion Outcomes Research Collaborative (TORC), a partnership with the Australian Red Cross Blood Service. This collaboration, established in 2008, has been central to the design and progress of pioneering transfusion research in Australia. TORC is overseen by a multidisciplinary steering committee chaired by A/Prof Merrole Cole-Sinclair of St Vincent’s Hospital, Melbourne. TORC’s setting, combining access to transfusion medicine and research expertise, provides opportunities for medical specialists in training and future researchers to develop solid foundations in transfusion research methodologies.
Gemma Crighton, Amber Degelia, Helen Haysom, Gordana Kel, Zoe McQuilten, Elizabeth Moore, Sally Nailon,
Rosemary Sparrow, Neil Waters, Erica Wood.