Research

Anaesthesia research
Prof Paul Myles and Dr Stefan Dieleman, Anaesthesia Research Fellow at Monash and Alfred, reviewing an echo result

The research unit is headed by Professor Paul Myles, and funded through a number of large NHMRC grants. Paul is supported by an NHMRC Practitioner Fellowship.

The unit is staffed by:

  • Sophie Wallace, Research Manager
  • Andrea Ditoro, Research Assistant
  • Catherine Farrington, Research Assistant
  • Wendy Gallagher, Research Assistant
  • Christina Halstead, Research Assistant
  • Jennifer Hunt, Research Assistant

Current research trials and studies

The unit manages and participates in numerous multicentre and local clinical trials and studies at any one time.

Obesity and Perioperative risk: a protocol for a systematic review

ATACAS Trial

Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial

ENIGMA-II  Trial

Nitrous oxide anaesthesia and cardiac morbidity after major surgery

RELIEF

Restrictive versus Liberal Fluid therapy in major abdominal surgery

POISE 2

POISE 2 is a large, international, placebo-controlled, factorial trial to assess the impact of clonidine and acetyl-salicylic acid (ASA) in patients undergoing noncardiac surgery who are at risk of a perioperative cardiovascular event.

BALANCED

The influence of anaesthetic depth on patient outcome after major surgery

Recovery after Major Surgery

Recovery and Well-being after Major Surgery: complications, functional recovery, and the measurement of disability-free survival. Recruiting 500 sequential patients from four centres, coordinated at the Department of Anaesthesia and Perioperative Medicine, Alfred Hospital. Funded through ANZCA

METS

Measurement of Exercise Tolerance for Surgery (METS) Study

To compare preoperative CPET to physicians’ subjective assessment of functional capacity for predicting postoperative 30-day death or non-fatal myocardial infarction in patients undergoing major elective non-cardiac surgery.

Iron NOF

Intravenous Iron to reduce transfusion and improve post-operative haemoglobin in patients with fractured Neck of Femur

To reduce the burden of red blood cell transfusion in patients with fractured neck of femur by the use of intravenous iron transfusion.

LICRA

Limiting I.V. Chloride to Reduce Acute kidney injury

The LICRA study aims to test the impact of a strategy of perioperative chloride-restriction through intravenous (IV) fluid therapy on the incidence of acute kidney injury after cardiac surgery. LICRA is a prospective, open-label, single-centre 4-period sequential study including all patients undergoing surgery by the Department of Cardiothoracic Surgery within the study period.  Available IV fluids are categorized as either chloride-rich or chloride-poor and the study involves a unit-wide policy switch in the type of administered intravenous fluid according to pre-defined calendar dates.

ISOS

International Surgical Outcomes Study

The primary outcome measure is in-hospital all cause mortality at 30 days following surgery. The secondary outcome measures are number of admissions to critical care and duration of hospital stay.

Proteolytic Mechanisms of Chronic Pain: Research Translation

The aim is to identify the body chemicals and proteins that play a key causative role in certain types of pain that people in hospital experience. These types of pain that we will focus on include nerve pain (neuropathic pain) and pain associated with significant tissue inflammation.

Registrar projects

In addition, registrars receive specialist training in  Anaesthesia, and each registrar must complete a research project as part of  their specialist qualifications. During 2013, seven projects were  completed, including randomised trials and audits.