Associate Professor Menno Van Zelm
Associate Professor Menno van Zelm
Laboratory Head: B cell differentiation
Phone: (03) 9903 0834
Department of Immunology
Level 6, Burnet Institute
89 Commercial Road
Melbourne Victoria 3004
Menno van Zelm performed his PhD studies at the Erasmus MC in Rotterdam, the Netherlands on "B cell development and primary antibody deficiencies" under supervision of Jacques van Dongen and Mirjam van der Burg. These studies resulted in new insights on stepwise human B cell differentiation in bone marrow, and on homeostatic and antigen-induced B cell proliferation with the newly developed KREC assay. Furthermore, Menno described the first antibody-deficient patients with CD19 gene defects. Between 2005 and 2007, he spent 18 months in the laboratory of Kees Murre at the University of California San Diego (UCSD) on the structural organization of the Ig heavy chain locus in developing B cells.
In 2008, A/Prof van Zelm returned to Rotterdam for postdoctoral studies on CD19-complex deficiencies and he identified the first CD81 deficiency. Since 2009, he heads a research group in the Erasmus MC (since 2013 as associate professor), and works on the regulation of Ig repertoire formation in precursor-B-cell development and the generation of memory B cells and plasma cells. Most studies involve human material to allow direct translation to patient care. Current disease models include antibody deficiencies, Down syndrome, persistent viral infections, auto-inflammatory diseases and IgE-mediated allergies.
A/Prof van Zelm has received multiple personal grants since 2009, including a Veni Fellowship from the Netherlands Organisation for Scientific Research (NWO). In 2010, he received the Heineken Young Scientists Award from the Royal Netherlands Academy of Sciences (KNAW).
Menno van Zelm is an academic editor for the international journals PLoS One, Frontiers in Immunology, and Immunology and Cell Biology. He is vice chair of the IUIS Nomenclature committee and a council member of the Human Cell Differentiation Molecules (HCDM) organisation that assigns new CD nomenclature and currently evaluates expression patterns of previously assigned CD markers in the CDMaps project.
Molecular aspects of memory B cells in health and disease
See Menno's ROPES profile
Rother MB, Palstra RJ, Jhunjhunwala S, van Kester KA, van IJcken WF, Hendriks RW, van Dongen JJ, Murre C, van Zelm MC. Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci. Nucleic Acids Res. 2015 Sep 17
van den Heuvel D, Driessen GJ, Berkowska MA, van der Burg M, Langerak AW, Zhao D, Charif H, Hartwig NG, van Rossum AM, Fraaij PL, van Dongen JJ, van Zelm MC. Persistent subclinical immune defects in HIV-1-infected children treated with antiretroviral therapy. AIDS. 2015 Sep 10;29(14):1745-56.
- Identification of immunological and genetic defects in patients with a primary antibody deficiency
- Immune cell monitoring in allergic patients before and during immunotherapy