Tumour Immunology Laboratory

Projects | Our people | Publications

The Tumour immunology laboratory focuses on the role of B cells and antibody production in cancer, and how these can be leveraged as novel biomarkers.

Projects

  1. Early detection and prognostication of cancers
  2. Prediction of clinical responses and toxicities to immunotherapy in cancer
  3. The role of B cells and antibody production in cancer
  4. The role of Tertiary Lymphoid Structures in solid tumours

Our people

Group Leader

Leave this here so that Accordion nested does not detect this CT as not existing.

Selected publications

  • Jessica Da Gama Duarte, Elnaz Tavancheh, Luke Quigley, Simone Ostrouska and Andreas Behren (2024). B cells and antibody production in cancers. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. DOI: 10.1007/978-3-030-80962-1_4-1.
  • Luke Quigley, Lokman Pang, Elnaz Tavancheh, Matthias Ernst, Andreas Behren, Jennifer Huynh, Jessica Da Gama Duarte (2023). Protocols for investigating tertiary lymphoid structures in human and mouse fixed tissue sections using OPAL™-TSA multiplex immunohistochemistry. STAR Protocols, Jan 10;4(1):101961. DOI: 10.1016/j.xpro.2022.101961. Online ahead of print. PMID: 36633948.
  • Kok Fei Chan, Jessica Da Gama Duarte, Simone Ostrouska and Andreas Behren (2022). Gamma-delta T cells in the tumor microenvironment – interactions with other immune cells. Frontiers in Immunology: 13:894315. DOI: 10.3389/fimmu.2022.894315.
  • Jessica Da Gama Duarte, Luke T. Quigley, Elnaz Tavancheh, Simone Ostrouska and Andreas Behren (2022). A multispectral immunohistochemistry panel to investigate γδ T cells and Butyrophilin molecules in the tumour microenvironment. Exploration of Immunology: 2:383–392. DOI: 10.37349/ei.2022.00057.
  • Oliver Klein, Damien Kee, Bo Gao, Ben Markman, Jessica Da Gama Duarte, Luke T. Quigley, Louise Jackett, Linda Mileshkin, Richelle Linklater, Jodie Palmer, Clare Scott, Matteo Carlino, Andreas Behren and Jonathan Cebon (2021). Combination immunotherapy with nivolumab and ipilimumab in patients with rare gynaecological malignancies: Results of the CA209-538 clinical trial. Journal for ImmunoTherapy of Cancer: 9:e003156. DOI: 10.1136/jitc-2021-003156. PMID: 34782426.
  • Jessica Da Gama Duarte, Luke T. Quigley, Anna Rachel Young, Masaru Hayashi, Mariko Miyzawa, Alex Lopata, Nuncio Mancuso, Mikio Mikami, Andreas Behren, Els Meeusen (2021). Identification of tumour antigens in ovarian cancers using local and circulating tumour-specific antibodies. International Journal of Molecular Science: 22, 11220. DOI: 10.3390/ijms222011220. PMID: 34681879.
  • Jessica Da Gama Duarte, Katherine Woods, Luke T. Quigley, Cyril Deceneux, Candani Tutuka, Tom Witkowski, Simone Ostrouska, Chris Hudson, Simon Chang-Hao Tsao, Anupama Pasam, Alexander Dobrovic, Jonathan M. Blackburn, Jonathan Cebon and Andreas Behren (2021). Ropporin-1 is a highly immunogenic and widely expressed antigen that induces specific antibody responses in melanoma patients. Cancers: 13(8), 1805. DOI: 10.3390/cancers13081805. PMID: 33918976.
  • Jennifer Mooi, Fiona Chionh, Peter Savas, Jessica Da Gama Duarte, Geoffrey Chong, Stephen Brown, Rachel Wong, Timothy Price, Alysson Wann, Effie Skrinos, John M. Mariadason and Niall C Tebbutt (2021). Dual anti-angiogenesis agents without chemotherapy in first-line treatment of metastatic colorectal cancer: results of a phase II study, with biomarker exploration. Clinical Cancer Research: 27(8):2159-2167. DOI: 10.1158/1078-0432.CCR-20-2714. PMID: 33514526.
  • Anna Rachel Young, Jessica Da Gama Duarte, Rhiannon Coulson, Megan O’Brien, Siddhartha Deb, Alex Lopata, Andreas Behren, Suresh Mathivanan, Elgene Lim and Els Meeusen (2019). Immunoprofiling of Breast Cancer Antigens Using Antibodies Derived from Local Lymph Nodes. Cancers: 11(5):682. DOI: 10.3390/cancers11050682. PMID 31100936.
  • Jessica da Gama Duarte, Janique Peyper, Jonathan M. Blackburn (2018) B cells and Antibody production in melanoma. Mammalian Genome: 29(11-12):790-805, DOI: 10.1007/s00335-018-9778-z. PMID: 30178304..
    Jessica Da Gama Duarte, Ryan W. Goosen, Peter J. Lawry and Jonathan M. Blackburn (2018). PMA: Protein Microarray Analyser - a user-friendly tool for data processing and normalization. BMC Research Notes: 11(1):156. DOI: 10.1186/s13104-018-3266-0. PMID: 29482592.
  • Jessica Da Gama Duarte, Sagun Parakh, Miles C. Andrews, Katherine Woods, Anupama Pasam, Candani Tutuka, Simone Ostrouska, Jonathan M Blackburn, Andreas Behren and Jonathan Cebon (2018). Autoantibodies may predict immune-related toxicity: results from a phase I study of Intralesional Bacillus Calmette-Guerin followed by ipilimumab in patients with advanced metastatic melanoma. Frontiers in Immunology: 9:411. DOI: 10.3389/fimmu.2018.00411. PMID: 29552014.
  • Jessica da Gama Duarte, Katherine Woods, Miles C. Andrews and Andreas Behren (2018). The good, the (not so) bad and the ugly of immune homeostasis in melanoma. Immunology & Cell Biology: 1-10; DOI: 10.1111/imcb.12001. PMID: 29392770.
  • Jessica G. Duarte & Jonathan M. Blackburn (2017). Advances in the development of human protein microarrays. Expert Review of Proteomics, 14(7):627-641, DOI: 10.1080/14789450.2017.1347042. PMID: 28644690.
  • Natasha Beeton-Kempen, Jessica G. Duarte, Aubrey Shoko, Jean-Michel Safari Serufuri, Tom John, Jonathan Cebon, Jonathan M. Blackburn (2014). Development of a novel, quantitative protein microarray platform for the multiplexed serological analysis of autoantibodies to cancer-testis antigens. International Journal of Cancer: 135(8):1842-51; DOI: 10.1002/ijc.28832, VC 2014 UICC. PMID: 24604332.