Medcalf Group - Molecular Neurotrauma, Haemostasis

Key terms: Fibrinolysis, stroke, traumatic brain injury (TBI)

2022 Medcalf group
2022 group L-R: Back row - Zikou (Oscar) Liu, Ahnaf Hossain, Sayan Thuraisamy, Rob Medcalf, Front row - Fiona McCutcheon, Joanne Chia, Heidi Ho, Charithani (Cherry) Keragala; Yunxin (Cindy) Xiao, Rachel Waring

Group Leader

Publications

Selected publications

For Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier video please click here

  • Mutimer, C., Keragala, C. B., Markus, H.S., Werring, D.J., Cloud, G.C., and Medcalf, R.L. (2021) Cerebral amyloid angiopathy and the fibrinolytic system: is plasmin a therapeutic target? Stroke 52(8):2707-2714. doi: 10.1161/STROKEAHA.120.033107
  • Medcalf, R.L. Keragala, C.B., and Myles, P.S. (2020). Fibrinolysis and COVID-19: A plasmin paradox. J Thromb Haemost. Sep;18(9):2118-2122. doi: 10.1111/jth.14960
  • Daglas, M, Galle, A., Draxler, D.F., Sashindranath, M., and Medcalf, R.L. (2020). Sex-dependent effects of tranexamic acid on blood-brain barrier permeability and the immune response following traumatic brain injury in mice. J Thromb Haemost Oct;18(10):2658-2671. doi: 10.1111/jth.15015.
  • Draxler, D.F., Yep, K., Hanafi, G., Winton, A., Daglas, M., Ho, H., Sashindranath, M., Wutzlhofer, L.M., Forbes, A., Goncalves, I., Tran, H., Wallace, S., Plebanski, M., Myles, P.S., Medcalf, R.L. (2019). Tranexamic acid modulates the immune response and reduces post-surgical infection rates. Blood Advances, 28;3(10):1598-1609. doi: 10.1182/bloodadvances.2019000092.
  • Daglas, M, Draxler, D.F., Ho, H., McCutcheon, F., Galle, A, Au, A-E, Larsson, P., Gregory, J., Alderuccio, F., Sashindranath, M, Medcalf, R.L. (2019). Activated CD8+ T cells cause long-term neurological dysfunction following traumatic brain injury. Cell Reports, Oct 29;29(5):1178-1191.e6. doi: 10.1016/j.celrep.2019.09.046
  • Draxler, D.F., Lee, F., Ho, H., Keragala, C.B., Medcalf, R.L., Niego, B. (2019).  t-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke. Frontiers Immunol. 10:591. doi: 10.3389/fimmu.2019.00591. eCollection 2019.
  • Draxler, D.F., Daglas, M., Fernando, A., Hanafi, G., McCutcheon, F., Ho, H., Galle, A., Au, A.-E., Niego, B., Wilson, K., Plebanski, M., Sashindranath, M., Medcalf, R.L. (2019). Tranexamic Acid Modulates the Cellular Immune Profile after Traumatic Brain Injury in Mice without Hyperfibrinolysis. J Thromb Haemost. 17(12):2174-2187 doi:10.1111/jth.14603.