Medcalf Group - Molecular Neurotrauma, Haemostasis

Key terms: Fibrinolysis, stroke, traumatic brain injury (TBI)

Medcalf group
2023 group L-R: Back row - Georgia Fitzpatrick, Rob Medcalf, Zikou Liu. Front row - Isabel Tippett, Orr Zaacs, Heidi Ho, Fiona McCutcheon, Fei Wu, Charithani Keragala Wu. Absent - Joanne Chia, Suhani Sharma.

Group Leader

Dean's Awards for Excellence in Research and Supervision

Prof Robert Medcalf won the 2019 Dean's Award for Excellence in Research (Postgraduate Research Supervision)

Prof Robert Medcalf won the 2020 Dean's Award for Excellence in Education - Honours Supervision.

YouTube video presentation (3:28 min): Prof Robert Medcalf won the 2020 Dean's Award for Excellence in Education - Honours Supervision



Selected publications

For Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier video please click here

  • McQuilten, Z.K., Venkatesh, B et al…, Medcalf, R.L et al Tong, S.Y.C. (100 co-authors) (2022). Anticoagulation strategies in Non-Critically ill patients with COVID-19. NEJM Evidence. EVIDoa2200293.
  • Smart, C., Mitchell, A., McCutcheon, F., Medcalf, R.L, Thiele, A. (2023). Tissue-type plasminogen activator induces conditioned receptive field plasticity in the mouse auditory cortex. iScience. 26, 105947
  • Coupland, L.A., Rabbolini, D., Crispin, P.J., Schoenecker, J.G., Miller, J.J., Ghent, T., Medcalf, R.L., Aneman, E.A. (2023). Point-of-care Diagnosis and Monitoring of Fibrinolysis Resistance in the Critically Ill: Results from a Feasibility Study. Critical Care 27:55 .
  • Mutimer, C., Keragala, C. B., Markus, H.S., Werring, D.J., Cloud, G.C., and Medcalf, R.L. (2021) Cerebral amyloid angiopathy and the fibrinolytic system: is plasmin a therapeutic target? Stroke 52(8):2707-2714. doi: 10.1161/STROKEAHA.120.033107
  • Medcalf, R.L. Keragala, C.B., and Myles, P.S. (2020). Fibrinolysis and COVID-19: A plasmin paradox. J Thromb Haemost. Sep;18(9):2118-2122. doi: 10.1111/jth.14960
  • Daglas, M, Galle, A., Draxler, D.F., Sashindranath, M., and Medcalf, R.L. (2020). Sex-dependent effects of tranexamic acid on blood-brain barrier permeability and the immune response following traumatic brain injury in mice. J Thromb Haemost Oct;18(10):2658-2671. doi: 10.1111/jth.15015.
  • Draxler, D.F., Yep, K., Hanafi, G., Winton, A., Daglas, M., Ho, H., Sashindranath, M., Wutzlhofer, L.M., Forbes, A., Goncalves, I., Tran, H., Wallace, S., Plebanski, M., Myles, P.S., Medcalf, R.L. (2019). Tranexamic acid modulates the immune response and reduces post-surgical infection rates. Blood Advances, 28;3(10):1598-1609. doi: 10.1182/bloodadvances.2019000092.
  • Daglas, M, Draxler, D.F., Ho, H., McCutcheon, F., Galle, A, Au, A-E, Larsson, P., Gregory, J., Alderuccio, F., Sashindranath, M, Medcalf, R.L. (2019). Activated CD8+ T cells cause long-term neurological dysfunction following traumatic brain injury. Cell Reports, Oct 29;29(5):1178-1191.e6. doi: 10.1016/j.celrep.2019.09.046
  • Draxler, D.F., Lee, F., Ho, H., Keragala, C.B., Medcalf, R.L., Niego, B. (2019).  t-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke. Frontiers Immunol. 10:591. doi: 10.3389/fimmu.2019.00591. eCollection 2019.
  • Draxler, D.F., Daglas, M., Fernando, A., Hanafi, G., McCutcheon, F., Ho, H., Galle, A., Au, A.-E., Niego, B., Wilson, K., Plebanski, M., Sashindranath, M., Medcalf, R.L. (2019). Tranexamic Acid Modulates the Cellular Immune Profile after Traumatic Brain Injury in Mice without Hyperfibrinolysis. J Thromb Haemost. 17(12):2174-2187 doi:10.1111/jth.14603.

Recent publications