Medcalf Group - Molecular Neurotrauma, Haemostasis

Key terms: Fibrinolysis, stroke, traumatic brain injury (TBI)

Medcalf group
2023 group L-R: Back row - Georgia Fitzpatrick, Rob Medcalf, Zikou Liu. Front row - Isabel Tippett, Orr Zaacs, Heidi Ho, Fiona McCutcheon, Fei Wu, Charithani Keragala Wu. Absent - Joanne Chia, Suhani Sharma.

Group Leader

Awards

Stroke Society of Australia (SSA) Award

Prof Robert Medcalf won the 2023 SSA Excellence in Stroke Award

Cardiovascular Science Award

Prof Robert Medcalf won the Heart Lung and Circulation 2023 Cardiovascular Science Award.

Dean's Awards for Excellence in Research and Supervision

Prof Robert Medcalf won the 2019 Dean's Award for Excellence in Research (Postgraduate Research Supervision).

Prof Robert Medcalf won the 2020 Dean's Award for Excellence in Education - Honours Supervision.


YouTube video presentation (3:28 min): Prof Robert Medcalf won the 2020 Dean's Award for Excellence in Education - Honours Supervision

Publications

Podcast

Selected publications since 2019

  • Gruen, R.L. Mitra, B., Bernard. S., et al, MEDCALF, R.L., Murray, L., Myles, P.S., Ng, S.J., Pitt, V., et al Trapani, T., Young, P.J.  (The PATCH-Trauma Study Investigators). (2023) Pre-hospital Tranexamic Acid for Severe Trauma. New Engl J Med Jul 13;389(2):127-136. doi: 10.1056/NEJMoa2215457. Epub 2023 Jun 14.
  • Liu, Z., McCutcheon, F.M., Ho, H., Chia. J., Xiao, Y., Tippett, I., Keragala,C.B., Cloud, G.C., MEDCALF, R.L (2023). Tranexamic acid in a mouse model of cerebral amyloid angiopathy: setting the stage for a novel stroke treatment. Res Pract Thromb Haemost Aug 9;7(6):102166. doi: 10.1016/j.rpth.2023.102166. eCollection 2023
  • Lam, T., Medcalf, R.L., Cloud, G.C., Myles, P.S., Keragala, C.B. (2023) Tranexamic acid for haemostasis and beyond: Does dose matter? Thrombosis J 21, 94. https://doi.org/10.1186/s12959-023-00540-0.
  • McQuilten, Z.K., Wood, E.M., and Medcalf, R.L. (2023). When to use tranexamic acid for the treatment of major bleeding? J. Thromb. Haemost 10:S1538-7836(23)00735-3. doi.org/10.1016/j.jtha.2023.10.001
  • Mutch N.J., and MEDCALF, R.L. (2023). The fibrinolysis Renaissance. J Thromb Haemost (in press) 2023
  • Lam, T., MEDCALF, R.L., Cloud, G.C., Myles, P.S., Keragala, C.B. (2023) Tranexamic acid for haemostasis and beyond: Does dose matter? Thrombosis J 21, 94. https://doi.org/10.1186/s12959-023-00540-0.
  • McQuilten, Z.K., Venkatesh, B et al…, MEDCALF, R.L et al Tong, S.Y.C. (100 co-authors) (2022). Anticoagulation strategies in Non-Critically ill patients with COVID-19. NEJM Evidence. EVIDoa2200293. doi.org/10.1056/EVIDoa2200293.
  • Coupland, L.A., Rabbolini, D., Crispin, P.J., Schoenecker, J.G., Miller, J.J., Ghent, T., Medcalf, R.L., Aneman, E.A. (2023). Point-of-care Diagnosis and Monitoring of Fibrinolysis Resistance in the Critically Ill: Results from a Feasibility Study. Critical Care 27:55 https://doi.org/10.1186/s13054-023-04329-5 .
  • Mutimer, C., Keragala, C. B., Markus, H.S., Werring, D.J., Cloud, G.C., and Medcalf, R.L. (2021) Cerebral amyloid angiopathy and the fibrinolytic system: is plasmin a therapeutic target? Stroke 52(8):2707-2714. doi: 10.1161/STROKEAHA.120.033107
  • Medcalf, R.L. Keragala, C.B., and Myles, P.S. (2020). Fibrinolysis and COVID-19: A plasmin paradox. J Thromb Haemost. Sep;18(9):2118-2122. doi: 10.1111/jth.14960
  • Daglas, M, Galle, A., Draxler, D.F., Sashindranath, M., and Medcalf, R.L. (2020). Sex-dependent effects of tranexamic acid on blood-brain barrier permeability and the immune response following traumatic brain injury in mice. J Thromb Haemost Oct;18(10):2658-2671. doi: 10.1111/jth.15015.
  • Draxler, D.F., Yep, K., Hanafi, G., Winton, A., Daglas, M., Ho, H., Sashindranath, M., Wutzlhofer, L.M., Forbes, A., Goncalves, I., Tran, H., Wallace, S., Plebanski, M., Myles, P.S., Medcalf, R.L. (2019). Tranexamic acid modulates the immune response and reduces post-surgical infection rates. Blood Advances, 28;3(10):1598-1609. doi: 10.1182/bloodadvances.2019000092.
  • Daglas, M, Draxler, D.F., Ho, H., McCutcheon, F., Galle, A, Au, A-E, Larsson, P., Gregory, J., Alderuccio, F., Sashindranath, M, Medcalf, R.L. (2019). Activated CD8+ T cells cause long-term neurological dysfunction following traumatic brain injury. Cell Reports, Oct 29;29(5):1178-1191.e6. doi: 10.1016/j.celrep.2019.09.046
  • Draxler, D.F., Lee, F., Ho, H., Keragala, C.B., Medcalf, R.L., Niego, B. (2019).  t-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke. Frontiers Immunol. 10:591. doi: 10.3389/fimmu.2019.00591. eCollection 2019.

Recent publications